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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Psen1tm1Zhe
targeted mutation 1, Hui Zheng
MGI:3623206
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Psen1tm1Zhe/Psen1tm1Zhe
Tg(APPSWE)2576Kha/?
involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:3624416


Genotype
MGI:3624416
cx1
Allelic
Composition
Psen1tm1Zhe/Psen1tm1Zhe
Tg(APPSWE)2576Kha/?
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Zhe mutation (0 available); any Psen1 mutation (22 available)
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• dramatically higher plaque density in brain compared to control Tg(APPSWE)2576Kahs transgenic mice (J:107251)
• numerous plaques could be detected in both the cortex and hippocampus at 10 month (J:107251)
• dramatically higher plaque density in brain compared to control Tg(APPSWE)2576Kahs transgenic mice (J:107251)
• numerous plaques could be detected in both the cortex and hippocampus at 10 month (J:107251)

homeostasis/metabolism
• dramatically higher plaque density in brain compared to control Tg(APPSWE)2576Kahs transgenic mice (J:107251)
• numerous plaques could be detected in both the cortex and hippocampus at 10 month (J:107251)
• dramatically higher plaque density in brain compared to control Tg(APPSWE)2576Kahs transgenic mice (J:107251)
• numerous plaques could be detected in both the cortex and hippocampus at 10 month (J:107251)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:107251





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory