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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arl3Gt(OST263303)Lex
gene trap OST263303, Lexicon Genetics
MGI:3623141
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Arl3Gt(OST263303)Lex/Arl3Gt(OST263303)Lex involves: 129S5/SvEvBrd MGI:3625687


Genotype
MGI:3625687
hm1
Allelic
Composition
Arl3Gt(OST263303)Lex/Arl3Gt(OST263303)Lex
Genetic
Background
involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arl3Gt(OST263303)Lex mutation (1 available); any Arl3 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• ones born alive all died by 3 weeks of age
• homozygous mutant mice were born at a sub-Mendelian ratio

growth/size/body
• widespread cystic dilation of pancreatic ducts and increased cell proliferation
• translucent and minute cystic structures throughout the renal cortex and medulla
• ones born alive are small and sickly
• ones born alive had markedly swollen abdomen
• a pronounced distention of their flanks caused by severe bilateral renomegaly within a few days of birth

renal/urinary system
• translucent and minute cystic structures throughout the renal cortex and medulla
• a pronounced distention of their flanks caused by severe bilateral renomegaly within a few days of birth
• numerous proliferating cells lined the cystic medullary collecting ducts as well as the cortical tubules and cystic glomeruli
• exhibited abnormal development of renal epithelial tubule structures

liver/biliary system
• in the liver the portal tracts were prominent
• ductal plate malformation were present in the biliary tract
• exhibited abnormal development of hepatic epithelial tubule structures
• the majority of epithelial cells lining the gall bladder and some extrahepatic bile ducts are proliferating
• extrahepatic bile ducts were dilated
• severely distended gall bladder, associated with a multifocal acute suppurative cholangitis
• multifocal acute suppurative cholangitis

endocrine/exocrine glands
• in the liver the portal tracts were prominent
• ductal plate malformation were present in the biliary tract
• exhibited abnormal development of hepatic epithelial tubule structures
• the majority of epithelial cells lining the gall bladder and some extrahepatic bile ducts are proliferating
• extrahepatic bile ducts were dilated
• severely distended gall bladder, associated with a multifocal acute suppurative cholangitis
• exhibited abnormal development of pancreatic epithelial tubule structures
• very small and consisted of dilated ducts and cysts surrounded by reduced amounts of parenchymal tissue
• widespread cystic dilation of pancreatic ducts and increased cell proliferation

vision/eye
• exhibit a paucity of outer segments at all retinal locations at postnatal day 9
• disks that were present appeared rudimentary at postnatal day 9
• lacked any detectable cone outer segments at postnatal day 13
• failed to show specific rod staining in outer segments at postnatal day 13
• dramatic increase in apoptotic cells in the outer nuclear layer at postnatal day 13

nervous system
• exhibit a paucity of outer segments at all retinal locations at postnatal day 9
• disks that were present appeared rudimentary at postnatal day 9
• lacked any detectable cone outer segments at postnatal day 13
• failed to show specific rod staining in outer segments at postnatal day 13

immune system
• multifocal acute suppurative cholangitis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive polycystic kidney disease DOID:0110861 OMIM:263200
J:107331





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory