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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arl3Gt(OST263303)Lex
gene trap OST263303, Lexicon Genetics
MGI:3623141
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Arl3Gt(OST263303)Lex/Arl3Gt(OST263303)Lex involves: 129S5/SvEvBrd MGI:3625687


Genotype
MGI:3625687
hm1
Allelic
Composition
Arl3Gt(OST263303)Lex/Arl3Gt(OST263303)Lex
Genetic
Background
involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arl3Gt(OST263303)Lex mutation (1 available); any Arl3 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• ones born alive all died by 3 weeks of age (J:107331)
• ones born alive all died by 3 weeks of age (J:107331)
• homozygous mutant mice were born at a sub-Mendelian ratio (J:107331)
• homozygous mutant mice were born at a sub-Mendelian ratio (J:107331)

growth/size/body
• ones born alive are small and sickly (J:107331)
• ones born alive are small and sickly (J:107331)
• ones born alive had markedly swollen abdomen (J:107331)
• ones born alive had markedly swollen abdomen (J:107331)

renal/urinary system
• numerous proliferating cells lined the cystic medullary collecting ducts as well as the cortical tubules and cystic glomeruli (J:107331)
• exhibited abnormal development of renal epithelial tubule structures (J:107331)
• numerous proliferating cells lined the cystic medullary collecting ducts as well as the cortical tubules and cystic glomeruli (J:107331)
• exhibited abnormal development of renal epithelial tubule structures (J:107331)
• a pronounced distention of their flanks caused by severe bilateral renomegaly within a few days of birth (J:107331)
• a pronounced distention of their flanks caused by severe bilateral renomegaly within a few days of birth (J:107331)
• translucent and minute cystic structures throughout the renal cortex and medulla (J:107331)
• translucent and minute cystic structures throughout the renal cortex and medulla (J:107331)

liver/biliary system
• in the liver the portal tracts were prominent (J:107331)
• ductal plate malformation were present in the biliary tract (J:107331)
• in the liver the portal tracts were prominent (J:107331)
• ductal plate malformation were present in the biliary tract (J:107331)
• exhibited abnormal development of hepatic epithelial tubule structures (J:107331)
• the majority of epithelial cells lining the gall bladder and some extrahepatic bile ducts are proliferating (J:107331)
• exhibited abnormal development of hepatic epithelial tubule structures (J:107331)
• the majority of epithelial cells lining the gall bladder and some extrahepatic bile ducts are proliferating (J:107331)
• extrahepatic bile ducts were dilated (J:107331)
• extrahepatic bile ducts were dilated (J:107331)
• severely distended gall bladder, associated with a multifocal acute suppurative cholangitis (J:107331)
• severely distended gall bladder, associated with a multifocal acute suppurative cholangitis (J:107331)
• multifocal acute suppurative cholangitis (J:107331)
• multifocal acute suppurative cholangitis (J:107331)

endocrine/exocrine glands
• in the liver the portal tracts were prominent (J:107331)
• ductal plate malformation were present in the biliary tract (J:107331)
• in the liver the portal tracts were prominent (J:107331)
• ductal plate malformation were present in the biliary tract (J:107331)
• exhibited abnormal development of hepatic epithelial tubule structures (J:107331)
• the majority of epithelial cells lining the gall bladder and some extrahepatic bile ducts are proliferating (J:107331)
• exhibited abnormal development of hepatic epithelial tubule structures (J:107331)
• the majority of epithelial cells lining the gall bladder and some extrahepatic bile ducts are proliferating (J:107331)
• extrahepatic bile ducts were dilated (J:107331)
• extrahepatic bile ducts were dilated (J:107331)
• severely distended gall bladder, associated with a multifocal acute suppurative cholangitis (J:107331)
• severely distended gall bladder, associated with a multifocal acute suppurative cholangitis (J:107331)
• exhibited abnormal development of pancreatic epithelial tubule structures (J:107331)
• exhibited abnormal development of pancreatic epithelial tubule structures (J:107331)
• very small and consisted of dilated ducts and cysts surrounded by reduced amounts of parenchymal tissue (J:107331)
• very small and consisted of dilated ducts and cysts surrounded by reduced amounts of parenchymal tissue (J:107331)
• widespread cystic dilation of pancreatic ducts and increased cell proliferation (J:107331)
• widespread cystic dilation of pancreatic ducts and increased cell proliferation (J:107331)

vision/eye
• exhibit a paucity of outer segments at all retinal locations at postnatal day 9 (J:107331)
• disks that were present appeared rudimentary at postnatal day 9 (J:107331)
• lacked any detectable cone outer segments at postnatal day 13 (J:107331)
• failed to show specific rod staining in outer segments at postnatal day 13 (J:107331)
• exhibit a paucity of outer segments at all retinal locations at postnatal day 9 (J:107331)
• disks that were present appeared rudimentary at postnatal day 9 (J:107331)
• lacked any detectable cone outer segments at postnatal day 13 (J:107331)
• failed to show specific rod staining in outer segments at postnatal day 13 (J:107331)
• dramatic increase in apoptotic cells in the outer nuclear layer at postnatal day 13 (J:107331)
• dramatic increase in apoptotic cells in the outer nuclear layer at postnatal day 13 (J:107331)

nervous system
• exhibit a paucity of outer segments at all retinal locations at postnatal day 9 (J:107331)
• disks that were present appeared rudimentary at postnatal day 9 (J:107331)
• lacked any detectable cone outer segments at postnatal day 13 (J:107331)
• failed to show specific rod staining in outer segments at postnatal day 13 (J:107331)
• exhibit a paucity of outer segments at all retinal locations at postnatal day 9 (J:107331)
• disks that were present appeared rudimentary at postnatal day 9 (J:107331)
• lacked any detectable cone outer segments at postnatal day 13 (J:107331)
• failed to show specific rod staining in outer segments at postnatal day 13 (J:107331)

immune system
• multifocal acute suppurative cholangitis (J:107331)
• multifocal acute suppurative cholangitis (J:107331)

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:107331





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory