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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Spta1sph-3J
spherocytosis 3 Jackson
MGI:3621484
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Spta1sph-3J/Spta1sph-3J NOD.Cg-H2b Spta1sph-3J MGI:4437828


Genotype
MGI:4437828
hm1
Allelic
Composition
Spta1sph-3J/Spta1sph-3J
Genetic
Background
NOD.Cg-H2b Spta1sph-3J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spta1sph-3J mutation (1 available); any Spta1 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• massive splenomegaly results from extensive expansion of the red pulp

hematopoietic system
• massive splenomegaly results from extensive expansion of the red pulp
• extramedullary hematopoietic foci are found in the liver
• severe hemolytic anemia with significantly decreased red blood cell count, hemoglobin and hematocrit
• high numbers of large reticulocytes and small shperocytes, anisocytosis polychromatophilia due to a high degree of reticulocytosis, poikilocytosis with many bizarrely shaped cells and fragments, increased red blood cell distribution width, spherocytic red blood cells with membrane loss, and frequent irregular sphero-eliptocytes are found, consistent with the abnormal red blood cell membrane skeletal composition, which includes not only diminished alpha spectrin but also diminished beta spectrin, band 3, beta adducin, gamma adducin, and decreased alpha adducin
• approximately one third of normal red blood cell concentration at 6 weeks of age
• approximately one third normal level at 6 weeks of age
• approximately one third the normal level of hemoglobin at 6 weeks of age

immune system
• massive splenomegaly results from extensive expansion of the red pulp

homeostasis/metabolism
• plasma iron levels are much higher than in controls
• extensive iron accumulation in the kidney

liver/biliary system

renal/urinary system
• extensive iron accumulation in the kidney





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory