Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb33tm1.1Bird mutation
(0 available);
any
Zbtb33 mutation
(2 available)
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normal phenotype
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• homozygous female mice exhibit no overt phenotype and are fertile; no differences in blood cell composition are detectable
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Allelic Composition |
ApcMin/Apc+ Zbtb33tm1.1Bird/Y
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Genetic Background |
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation
(12 available);
any
Apc mutation
(154 available)
Zbtb33tm1.1Bird mutation
(0 available);
any
Zbtb33 mutation
(2 available)
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mortality/aging
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• life span of these animals is an average of 317 days; this is improved over ApcMin mice alone at an average of 217 days
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neoplasm
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• mice exhibit a similar number of intestinal tumors as compared to ApcMin mice
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• tumors in doubly heterozygous mice significantly smaller at 180 days of age
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digestive/alimentary system
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• mice exhibit a similar number of intestinal tumors as compared to ApcMin mice
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Allelic Composition |
Zbtb33tm1.1Bird/Y
|
|
Genetic Background |
involves: 129P2/OlaHsd * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb33tm1.1Bird mutation
(0 available);
any
Zbtb33 mutation
(2 available)
|
|
|
normal phenotype
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• hemizygous male mice exhibit no overt phenotype and are fertile; no differences in blood cell composition are detectable
• hemizygous ES cells exhibit no significant differences from controls in neural specificaton, viability or neuronal or glial cell differentiation
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