Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Postntm1Sjc mutation
(0 available);
any
Postn mutation
(52 available)
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skeleton
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• mutants fed a soft diet show alterations of the crestal alveolar bone and the deeper alveolar bone and cementum-enamel junction, particularly around the proximal root of the first molar
• mutants fed a soft diet exhibit a higher distance between the molar root and the enamel of the underlying incisor, indicating alveolar bone alteration
• treatment with zoledronate improves systemic and alveolar bone alterations in ovariectomized mice without producing jaw bone necrosis
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• 13 month old mutants fed a soft diet show some inflammatory infiltrates around the periodontal ligament but no signs of active inflammation in gingival, periradicular and jaw bone compartments indicating absence of overt periodontal disease
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• mutants fed a soft diet exhibit alteration of the enamel that affects the incisor from the apex to the incisor edge
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• large medullar spaces filled by fibrous tissue are seen in the mandibles of mutants fed a soft diet, whereas no fibrous tissue is seen in wild-type mice
• mutants fed a soft diet exhibit lower basal and alveolar bone volume fraction in the mandible
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• mutants fed a soft diet have a higher osteoclast number in the bone area between the molar root and the enamel of the underlying incisor
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• mutants fed a soft diet exhibit alveolar and systemic osteopenia without overt periodontal disease
• intact and ovariectomized females exhibit lower femur bone mineral density
• treatment with zoledronate improves bone mineral density, femur trabecular bone volume on tissue volume and cortical bone volume in both wild-type and mutant ovariectomized females
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• intact and ovariectomized females exhibit lower femur bone mineral density
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• intact and ovariectomized females exhibit lower cortical bone microarchitecture
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• intact and ovariectomized females exhibit lower trabecular bone microarchitecture
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• mutants fed a soft diet exhibit lower bone formation indices in the mandibles
• intact and ovariectomized females exhibit decreased bone formation indices in the femur and mandible
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craniofacial
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• mutants fed a soft diet show alterations of the crestal alveolar bone and the deeper alveolar bone and cementum-enamel junction, particularly around the proximal root of the first molar
• mutants fed a soft diet exhibit a higher distance between the molar root and the enamel of the underlying incisor, indicating alveolar bone alteration
• treatment with zoledronate improves systemic and alveolar bone alterations in ovariectomized mice without producing jaw bone necrosis
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• 13 month old mutants fed a soft diet show some inflammatory infiltrates around the periodontal ligament but no signs of active inflammation in gingival, periradicular and jaw bone compartments indicating absence of overt periodontal disease
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• mutants fed a soft diet exhibit alteration of the enamel that affects the incisor from the apex to the incisor edge
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• large medullar spaces filled by fibrous tissue are seen in the mandibles of mutants fed a soft diet, whereas no fibrous tissue is seen in wild-type mice
• mutants fed a soft diet exhibit lower basal and alveolar bone volume fraction in the mandible
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hematopoietic system
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• mutants fed a soft diet have a higher osteoclast number in the bone area between the molar root and the enamel of the underlying incisor
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immune system
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• mutants fed a soft diet have a higher osteoclast number in the bone area between the molar root and the enamel of the underlying incisor
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growth/size/body
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• mutants fed a soft diet show alterations of the crestal alveolar bone and the deeper alveolar bone and cementum-enamel junction, particularly around the proximal root of the first molar
• mutants fed a soft diet exhibit a higher distance between the molar root and the enamel of the underlying incisor, indicating alveolar bone alteration
• treatment with zoledronate improves systemic and alveolar bone alterations in ovariectomized mice without producing jaw bone necrosis
|
|
|
• 13 month old mutants fed a soft diet show some inflammatory infiltrates around the periodontal ligament but no signs of active inflammation in gingival, periradicular and jaw bone compartments indicating absence of overt periodontal disease
|
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• mutants fed a soft diet exhibit alteration of the enamel that affects the incisor from the apex to the incisor edge
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Postntm1Sjc mutation
(0 available);
any
Postn mutation
(52 available)
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mortality/aging
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• about 14% of pups die within 2 to 3 weeks of birth
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growth/size/body
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• progressive enamel defect resulting in a decreased mesial-distal area and the presence of a mandibular incisor interproximal space
• at 5 months, the incisal edge is abnormally worn and the enamel surface is deformed and cleft
• incisor canals are obliterated
• placing mice on a soft powdered chow diet reduced the severity of defects
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• at 4 weeks of age fully erupted molar roots show signs of resorption
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• at 4 weeks of age fully erupted molars display widening of the periodontal ligament
• at 3 months of age, high levels of inflammatory infiltrate, primarily consisting of neutrophils, are seen in the periodontal ligament
• presence of this infiltrate results in local conversion of the periodontal ligament to granulation tissue
• foreign particles, such as hair shafts, are seen in the periodontal ligament
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• structural defects are detected by spectroscopy; however, calcium and phosphate content are not significantly different from wild-type
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• backscatter scanning electron microscopic images indicate a hypermineralization of the dentin
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• progressive incisor enamel defect that result in deformation of the entire facial enamel surface of the upper and lower incisors
• no defect is apparent before weaning
• initially the enamel shows a hypoplastic like condition with decreased translucence and a reduced incisor mesial-distal area
• by 5 months, a highly radiopaque deformed and cleft surface extends from the apex forward to the incisal edge
• also at 5 months the incisor enamel surface is thinner with an irregular and poorly defined structure
• on a powdered soft chow diet only mild clefting of the enamel is seen
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• in adult mice, the enamel epithelium has a psuedostratified structure that appears to produce an amorphous matrix that covers the dentin and is ectopically present within the epithelium
• however, at 2 weeks of age the ameloblast layer appears similar to wild-type
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• at 3 months of age radiographic signs of external root resorption are seen and a significant increase in osteoclast activity is seen in the periodontium
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• 12 week old mice are about 15 - 30% smaller than wild-type
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• 12 week old mice weigh about 50% less than wild-type mice
• placing mice on a soft powdered chow diet decreases the difference in body weight
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• growth rate declines around weaning
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skeleton
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• on average the adult skull is about 7% shorter and 15% narrower than wild-type littermates
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• progressive enamel defect resulting in a decreased mesial-distal area and the presence of a mandibular incisor interproximal space
• at 5 months, the incisal edge is abnormally worn and the enamel surface is deformed and cleft
• incisor canals are obliterated
• placing mice on a soft powdered chow diet reduced the severity of defects
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• at 4 weeks of age fully erupted molar roots show signs of resorption
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• at 4 weeks of age fully erupted molars display widening of the periodontal ligament
• at 3 months of age, high levels of inflammatory infiltrate, primarily consisting of neutrophils, are seen in the periodontal ligament
• presence of this infiltrate results in local conversion of the periodontal ligament to granulation tissue
• foreign particles, such as hair shafts, are seen in the periodontal ligament
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|
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• structural defects are detected by spectroscopy; however, calcium and phosphate content are not significantly different from wild-type
|
|
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• backscatter scanning electron microscopic images indicate a hypermineralization of the dentin
|
|
|
• progressive incisor enamel defect that result in deformation of the entire facial enamel surface of the upper and lower incisors
• no defect is apparent before weaning
• initially the enamel shows a hypoplastic like condition with decreased translucence and a reduced incisor mesial-distal area
• by 5 months, a highly radiopaque deformed and cleft surface extends from the apex forward to the incisal edge
• also at 5 months the incisor enamel surface is thinner with an irregular and poorly defined structure
• on a powdered soft chow diet only mild clefting of the enamel is seen
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• in adult mice, the enamel epithelium has a psuedostratified structure that appears to produce an amorphous matrix that covers the dentin and is ectopically present within the epithelium
• however, at 2 weeks of age the ameloblast layer appears similar to wild-type
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• at 3 months of age radiographic signs of external root resorption are seen and a significant increase in osteoclast activity is seen in the periodontium
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• about 16% shorter than in wild-type littermates with fewer trabeculae at 4 months of age
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• about 11% shorter than in wild-type littermates with fewer trabeculae at 4 months of age
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• about 11% shorter than in wild-type littermates with fewer trabeculae at 4 months of age
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• about 11% shorter than in wild-type littermates with fewer trabeculae at 4 months of age
• placing mice on a soft powdered chow diet results in bone length similar to wild-type
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• about 11% shorter than in wild-type littermates with fewer trabeculae at 4 months of age
• placing mice on a soft powdered chow diet results in bone length similar to wild-type
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• about 23% smaller than in wild-type littermates at 4 months of age
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• at 4 months of age ribs have smaller growth plates, and contain fewer trabeculae compared to wild-type littermates
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• 22% narrower in diameter
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• trabeculae are reduced in the ribs and limb bones
• placing mice on a soft powdered chow diet grossly rescues the cancellous bone defects
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• rib growth plates are smaller
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cardiovascular system
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• acellular deposits of extracellular matrix produce discontinuities in the valve leaflets and ectopic islands of Acta1 positive cells are found in the leaflets
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muscle
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N |
• myotendinous junctions and the periosteum are similar to wild-type
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reproductive system
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• smaller, in proportion with overall reduction in body size
• histology appears normal
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• smaller, in proportion with overall reduction in body size
• histology appears normal
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• smaller, in proportion with overall reduction in body size
• however, histology appears normal and the proliferative phase occurs as normal
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• vaginal plugs abnormally persist for up to 3 days
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• females fail to cycle; however, folliculogenesis appears intact
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• despite plugs and the presence of 2- and 4-cell zygotes no implantation sites are detected at 6 to 10 days after plug detection
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• on a powdered soft chow diet some female are able to carry and deliver pups and litter sizes are similar to wild-type but fecundity is reduced to 1.7 +/- 0.5 litters/female compared to 3.1 +/- 0.6 litters/female for wild-type mice on a standard chow diet
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immune system
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• at 3 months of age, high levels of inflammatory infiltrate, primarily consisting of neutrophils, are seen in the periodontal ligament
• presence of this infiltrate results in local conversion of the periodontal ligament to granulation tissue
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endocrine/exocrine glands
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N |
• histology of the gonads, thyroid glands and pituitaries is normal
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• smaller, in proportion with overall reduction in body size
• histology appears normal
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limbs/digits/tail
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• about 16% shorter than in wild-type littermates with fewer trabeculae at 4 months of age
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• about 11% shorter than in wild-type littermates with fewer trabeculae at 4 months of age
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• about 11% shorter than in wild-type littermates with fewer trabeculae at 4 months of age
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• about 11% shorter than in wild-type littermates with fewer trabeculae at 4 months of age
• placing mice on a soft powdered chow diet results in bone length similar to wild-type
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• about 11% shorter than in wild-type littermates with fewer trabeculae at 4 months of age
• placing mice on a soft powdered chow diet results in bone length similar to wild-type
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craniofacial
|
|
• on average the adult skull is about 7% shorter and 15% narrower than wild-type littermates
|
|
|
• progressive enamel defect resulting in a decreased mesial-distal area and the presence of a mandibular incisor interproximal space
• at 5 months, the incisal edge is abnormally worn and the enamel surface is deformed and cleft
• incisor canals are obliterated
• placing mice on a soft powdered chow diet reduced the severity of defects
|
|
|
• at 4 weeks of age fully erupted molar roots show signs of resorption
|
|
|
• at 4 weeks of age fully erupted molars display widening of the periodontal ligament
• at 3 months of age, high levels of inflammatory infiltrate, primarily consisting of neutrophils, are seen in the periodontal ligament
• presence of this infiltrate results in local conversion of the periodontal ligament to granulation tissue
• foreign particles, such as hair shafts, are seen in the periodontal ligament
|
|
|
• structural defects are detected by spectroscopy; however, calcium and phosphate content are not significantly different from wild-type
|
|
|
• backscatter scanning electron microscopic images indicate a hypermineralization of the dentin
|
|
|
• progressive incisor enamel defect that result in deformation of the entire facial enamel surface of the upper and lower incisors
• no defect is apparent before weaning
• initially the enamel shows a hypoplastic like condition with decreased translucence and a reduced incisor mesial-distal area
• by 5 months, a highly radiopaque deformed and cleft surface extends from the apex forward to the incisal edge
• also at 5 months the incisor enamel surface is thinner with an irregular and poorly defined structure
• on a powdered soft chow diet only mild clefting of the enamel is seen
|
|
|
• in adult mice, the enamel epithelium has a psuedostratified structure that appears to produce an amorphous matrix that covers the dentin and is ectopically present within the epithelium
• however, at 2 weeks of age the ameloblast layer appears similar to wild-type
|
|
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• at 3 months of age radiographic signs of external root resorption are seen and a significant increase in osteoclast activity is seen in the periodontium
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Analysis Tools