Postntm1Sjc
Targeted Allele Detail
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Symbol: |
Postntm1Sjc |
Name: |
periostin, osteoblast specific factor; targeted mutation 1, Simon J Conway |
MGI ID: |
MGI:3611751 |
Synonyms: |
PerilacZ, periostin-, Postn-, PostnLacZ |
Gene: |
Postn Location: Chr3:54268530-54298458 bp, + strand Genetic Position: Chr3, 25.46 cM
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Alliance: |
Postntm1Sjc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:103753
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A promoterless IRES-lacZ-neo-loxP cassette replaced the translation start site and all of the first exon and about 300 bp of the first intron. Western blot analysis failed to detect protein in newborn mutants. Whole-embryo staining showed widespread expression, particularly within the peripheral nervous system, craniofacial region, dermis of the skin, and body cavities.
(J:103753)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Postn Mutation: |
52 strains or lines available
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Original: |
J:103753 Rios H, et al., periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Mol Cell Biol. 2005 Dec;25(24):11131-44 |
All: |
30 reference(s) |
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