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Allele Symbol Allele Name Allele ID |
Taf10tm1Lzt targeted mutation 1, Laszlo Tora MGI:3606185 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• do not observe any defects in keratinocyte proliferation and differentiation of homeostatic, UV-exposed and regenerating adult skin in mice in which Taf10 is selectively ablated in epidermal keratinocytes of adults
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neonates die within 3-4 hours after being removed from their mothers in contrast to controls that survive for more than 24 hours
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• fetuses have a 15-fold higher transepidermal water loss than controls
• fetuses lose 7% body weight within 4 hours after cesarean delivery at E18.5 while controls maintain their body weight
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• extensive penetration of X-Gal dye in newborns compared to controls
• fetuses have a 15-fold higher transepidermal water loss than controls
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• extensive penetration of X-Gal dye in newborns compared to controls
• fetuses have a 15-fold higher transepidermal water loss than controls
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• no multilamellar structures are seen between granular cells and corneocytes, only vesicles are located in the intracellular spaces
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• terminal differentiation of keratinocytes is impaired
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• cornified cell layer is always reduced or absent in about 70% of the skin surface
• in the remaining cornified layer, lipid lamellae are either not formed or highly variable in thickness and contain 10-fold less corneodesmosomes than controls
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• cornified cell layer is always reduced or absent in about 70% of the skin surface
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• approximately 80% of lamellar granules do not contain lipid disks
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• skin of neonates is more sticky than controls
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• terminal differentiation of keratinocytes is impaired
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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