Mouse Genome Informatics
hm1
    Kcnq2tm1Dgen/Kcnq2tm1Dgen
B6.129P2-Kcnq2tm1Dgen/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• the peak amplitude of apamin-insensitivie medium afterhyperpolarization current of dentate gyrus granule cells is decreased compared to in wild-type mice
• however, apamin-insensitive medium afterhyperpolarization currents in CA1 pyramidal cells are normal
• apamin-insensitive slow afterhyperpolarization current of dentate gyrus granule cells is reduced 50% compared to in wild-type cells


Mouse Genome Informatics
hm2
    Kcnq2tm1Dgen/Kcnq2tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• homozygotes frequently are not found at weaning


Mouse Genome Informatics
ht3
    Kcnq2tm1Dgen/Kcnq2+
B6.129P2-Kcnq2tm1Dgen/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at the 78, 86, and 90 dB prepulse levels
• however, in the absence of a prepulse acoustic startle responses are normal


Mouse Genome Informatics
ht4
    Kcnq2tm1Dgen/Kcnq2+
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• heterozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice

nervous system
• heterozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice