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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kcnq2tm1Dgen
targeted mutation 1, Deltagen
MGI:3604594
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kcnq2tm1Dgen/Kcnq2tm1Dgen B6.129P2-Kcnq2tm1Dgen/J MGI:3830651
hm2
Kcnq2tm1Dgen/Kcnq2tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606652
ht3
Kcnq2tm1Dgen/Kcnq2+ B6.129P2-Kcnq2tm1Dgen/J MGI:4818911
ht4
Kcnq2tm1Dgen/Kcnq2+ involves: 129P2/OlaHsd * C57BL/6 MGI:3606653


Genotype
MGI:3830651
hm1
Allelic
Composition
Kcnq2tm1Dgen/Kcnq2tm1Dgen
Genetic
Background
B6.129P2-Kcnq2tm1Dgen/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation (1 available); any Kcnq2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the peak amplitude of apamin-insensitivie medium afterhyperpolarization current of dentate gyrus granule cells is decreased compared to in wild-type mice (J:142688)
• however, apamin-insensitive medium afterhyperpolarization currents in CA1 pyramidal cells are normal (J:142688)
• apamin-insensitive slow afterhyperpolarization current of dentate gyrus granule cells is reduced 50% compared to in wild-type cells (J:142688)
• the peak amplitude of apamin-insensitivie medium afterhyperpolarization current of dentate gyrus granule cells is decreased compared to in wild-type mice (J:142688)
• however, apamin-insensitive medium afterhyperpolarization currents in CA1 pyramidal cells are normal (J:142688)
• apamin-insensitive slow afterhyperpolarization current of dentate gyrus granule cells is reduced 50% compared to in wild-type cells (J:142688)




Genotype
MGI:3606652
hm2
Allelic
Composition
Kcnq2tm1Dgen/Kcnq2tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation (1 available); any Kcnq2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes frequently are not found at weaning (J:101679)
• homozygotes frequently are not found at weaning (J:101679)




Genotype
MGI:4818911
ht3
Allelic
Composition
Kcnq2tm1Dgen/Kcnq2+
Genetic
Background
B6.129P2-Kcnq2tm1Dgen/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation (1 available); any Kcnq2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at the 78, 86, and 90 dB prepulse levels (J:161844)
• however, in the absence of a prepulse acoustic startle responses are normal (J:161844)
• at the 78, 86, and 90 dB prepulse levels (J:161844)
• however, in the absence of a prepulse acoustic startle responses are normal (J:161844)




Genotype
MGI:3606653
ht4
Allelic
Composition
Kcnq2tm1Dgen/Kcnq2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation (1 available); any Kcnq2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• heterozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice (J:101679)
• heterozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice (J:101679)

nervous system
• heterozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice (J:101679)
• heterozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice (J:101679)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory