Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation
(1 available);
any
Kcnq2 mutation
(47 available)
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nervous system
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• the peak amplitude of apamin-insensitivie medium afterhyperpolarization current of dentate gyrus granule cells is decreased compared to in wild-type mice
• however, apamin-insensitive medium afterhyperpolarization currents in CA1 pyramidal cells are normal
• apamin-insensitive slow afterhyperpolarization current of dentate gyrus granule cells is reduced 50% compared to in wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation
(1 available);
any
Kcnq2 mutation
(47 available)
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mortality/aging
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• homozygotes frequently are not found at weaning
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation
(1 available);
any
Kcnq2 mutation
(47 available)
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nervous system
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• at the 78, 86, and 90 dB prepulse levels
• however, in the absence of a prepulse acoustic startle responses are normal
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Allelic
Composition |
Kcnq2tm1Dgen/Kcnq2+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation
(1 available);
any
Kcnq2 mutation
(47 available)
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behavior/neurological
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• heterozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice
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nervous system
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• heterozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice
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Analysis Tools