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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptch2tm1Dgen
targeted mutation 1, Deltagen
MGI:3604587
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ptch2tm1Dgen/Ptch2tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606646


Genotype
MGI:3606646
hm1
Allelic
Composition
Ptch2tm1Dgen/Ptch2tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch2tm1Dgen mutation (1 available); any Ptch2 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• at 49 days of age spleen size, weight, and spleen weight to body weight ratio are increased in homozygous males
• a moderate to severe diffuse increase in extramedullary hematopoiesis is seen in homozygous males at 49 days of age
• in homozygous males at 49 days of age hemoglobin, hematocrit, and red blood cell count are decreased
• at 49 days of age the bone marrow myeloid:erythroid ratio is increased in homozygous males
• mild red blood cell abnormalities including anisocytosis, poikilocytosis, and polychromasia are seen in homozygous males at 49 days of age
• seen in homozygous males at 49 days of age
• seen in homozygous males at 49 days of age
• the percentage of neutrophils is mildly to moderately increased in homozygous males at 49 days of age

immune system
• at 49 days of age spleen size, weight, and spleen weight to body weight ratio are increased in homozygous males
• the percentage of neutrophils is mildly to moderately increased in homozygous males at 49 days of age

growth/size/body
• at 49 days of age spleen size, weight, and spleen weight to body weight ratio are increased in homozygous males





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory