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Allele Symbol Allele Name Allele ID |
Slc22a6tm1Dgen targeted mutation 1, Deltagen MGI:3604571 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the level of urinary urate is decreased 30% compared to in wild-type mice
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• the level of urinary urate is decreased 30% compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all homozygous males have increased thymus weight and thymus to body weight ratio, while females have slightly increased thymus to body weight ratio
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• all homozygous males have increased thymus weight and thymus to body weight ratio, while females have slightly increased thymus to body weight ratio
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• all homozygous males have increased thymus weight and thymus to body weight ratio, while females have slightly increased thymus to body weight ratio
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in vivo and renal slice excretion of para-aminohippurate (PAH) is significantly reduced; however, excretion of estrone sulfate, inulin clearance, blood pressure, heart rate and kidney morphology are all normal
• also, no differences are seen in body weight or in plasma or urinary electrolyte, creatinine, or glucose levels and histology of the kidneys, heart, liver, spleen, muscle, and brain appears normal
• higher concentrations of furosemide are required to induce similar levels natriuresis compared to wild-type mice
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• in vivo and renal slice excretion of para-aminohippurate (PAH) is significantly reduced; however, excretion of estrone sulfate, inulin clearance, blood pressure, heart rate and kidney morphology are all normal
• also, no differences are seen in body weight or in plasma or urinary electrolyte, creatinine, or glucose levels and histology of the kidneys, heart, liver, spleen, muscle, and brain appears normal
• higher concentrations of furosemide are required to induce similar levels natriuresis compared to wild-type mice
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• higher concentrations of furosemide are required to induce similar levels natriuresis compared to wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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