Phenotypes associated with this allele

• Allele Symbol: Tpp1^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3604537
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpp1^tm1Dgen/Tpp1^tm1Dgen	involves: 129S1/Sv * C57BL/6	MGI:3606473

Genotype
MGI:3606473

hm1

• Allelic Composition: Tpp1^tm1Dgen/Tpp1^tm1Dgen
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:101679 )

• death at 100 to 130 days, mainly homozygous females

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:101679 )

tremors ( J:101679 )

• at 100-130 days of age, homozygous males

• at 121-149 days of age, homozygous females

ataxia ( J:101679 )

• at 100-130 days of age, homozygous females

impaired coordination ( J:101679 )

• lack of coordination at 121-149 days of age, mainly homozygous females

weakness ( J:101679 )

• at 100-130 days of age, homozygous males and females

hunched posture ( J:101679 )

• at 100-130 days of age, homozygous female and males

• at 121-149 days of age, homozygous females

abnormal locomotor activation ( J:101679 )

• at 100-130 days of age, abnormal activity levels is seen in homozygous females

abnormal gait ( J:101679 )

• at 100-130 days of age and at 121-149 days of age, homozygous males

increased thermal nociceptive threshold ( J:101679 )

• at 49 days of age, a significant increase in thermal response latency during tail flick testing when compared with age- and gender-matched wild-type control mice, indicating a possible increased pain threshold phenotype

seizures ( J:101679 )

• seizure-like behavior at 121-149 days of age, mainly homozygous females

respiratory system

tachypnea ( J:101679 )

• at 121-149 days of age, mainly homozygous females

respiratory distress ( J:101679 )

• gasping at 100-130 days of age, homozygous female

nervous system

seizures ( J:101679 )

• seizure-like behavior at 121-149 days of age, mainly homozygous females

homeostasis/metabolism

dehydration ( J:101679 )

• at 100-130 days of age, homozygous female