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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adipor1tm1Dgen
targeted mutation 1, Deltagen
MGI:3604517
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adipor1tm1Dgen/Adipor1tm1Dgen B6.129P2-Adipor1tm1Dgen/Mmnc MGI:3713860
hm2
Adipor1tm1Dgen/Adipor1tm1Dgen involves: 129P2/OlaHsd MGI:6106866
hm3
Adipor1tm1Dgen/Adipor1tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606562


Genotype
MGI:3713860
hm1
Allelic
Composition
Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic
Background
B6.129P2-Adipor1tm1Dgen/Mmnc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipor1tm1Dgen mutation (1 available); any Adipor1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• during light and dark phase, energy expenditure is decreased
• however, respiratory exchange ratio is unchanged
• male mice have a 35% higher glucose response than in wild-type mice
• females have increased plasma cholesterol
• liver triglyceride levels are increased

adipose tissue
• in males and females at 31 weeks
• in males and females at 31 weeks

behavior/neurological
• mice have decreased spontaneous locomotor activity and more time spent in corners of the cages

growth/size/body
• males, but not females, have increased body weight despite similar food intake as wild-type controls

liver/biliary system
• liver triglyceride levels are increased




Genotype
MGI:6106866
hm2
Allelic
Composition
Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipor1tm1Dgen mutation (1 available); any Adipor1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice treated with isopropanol exhibit less of an increase in interscapular brown adipose tissue compared with similarly treated wild-type mice
• cold-exposed mice exhibit lower core body temperatures compared with similarly treated wild-type mice
• however, deletion of adiponectin restored cold-adaptation
• in serum and interscapular brown adipose tissue




Genotype
MGI:3606562
hm3
Allelic
Composition
Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipor1tm1Dgen mutation (1 available); any Adipor1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory