Analysis Tools
mortality/aging
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• embryonic death between E9.5 and E10.5
(J:101679)
• homozygotes found at E10.5 were resorbing
(J:101679)
• die around E10.5 - E11.0
(J:186473)
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cardiovascular system
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• at E9.5, paired dorsal aortas show marked dilation and narrowing with clumps of blood cells frequently seen in the caudal region
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• expression analysis indicates defects in arterial differentiation and maturation
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• mural layers surrounding the aorta are thinner at E9.5
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• coarse vascular patterns indicative of impaired remodeling are seen at E9.5
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• absence of large vessels at E10.5
• dilation of vessels
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• at E10.5
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• mural layers surrounding the myocardium are thinner at E9.5
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• poorly formed at E9.5
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• at E9.5
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• massive pericardial effusion at E10.5
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embryo
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• absence of large vessels at E10.5
• dilation of vessels
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• at E10.5
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• detachment of endodermal and mesodermal layers at E9.5
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• coarse vascular patterns indicative of impaired remodeling are seen at E9.5
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growth/size/body
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• at E9.5
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• at E10.5
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homeostasis/metabolism
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• massive pericardial effusion at E10.5
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muscle
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• poorly formed at E9.5
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