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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgfr2tm2Cxd
targeted mutation 2, Chu-Xia Deng
MGI:3604072
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Fgfr2tm2Cxd/Fgfr2+
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S6/SvEvTac * FVB/N MGI:3604078


Genotype
MGI:3604078
cn1
Allelic
Composition
Fgfr2tm2Cxd/Fgfr2+
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm2Cxd mutation (0 available); any Fgfr2 mutation (20 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants with severe cranial abnormalities die within 20 days of birth, less severely affected mutants survive to adulthood (J:101385)
• mutants with severe cranial abnormalities die within 20 days of birth, less severely affected mutants survive to adulthood (J:101385)

growth/size/body
• midface hypoplasia (J:101385)
• midface hypoplasia (J:101385)
• severely affected mutants are very small compared to wild-type mice, less severely affected mutants are 70-80% of the size of wild-type littermates (J:101385)
• severely affected mutants are very small compared to wild-type mice, less severely affected mutants are 70-80% of the size of wild-type littermates (J:101385)

skeleton
• some adults have asymmetrical skulls; however no obvious hand/foot abnormalities are seen (J:101385)
• some adults have asymmetrical skulls; however no obvious hand/foot abnormalities are seen (J:101385)
• at P1 and P8 increased apoptosis is seen with the highest levels seen in the parietal and frontal bones; however no significant difference in osteoblast proliferation (at E16.5, E18.5, P1, P5, and P8) or differentiation (at E18.5, P1, and P18) is seen in the sutures (J:101385)
• at P1 and P8 increased apoptosis is seen with the highest levels seen in the parietal and frontal bones; however no significant difference in osteoblast proliferation (at E16.5, E18.5, P1, P5, and P8) or differentiation (at E18.5, P1, and P18) is seen in the sutures (J:101385)
• premature closure of the coronal suture is first seen around E18.5 with more significant overlap between the osteogenic fronts developing over time and fewer mesenchymal cells are found in the coronal suture at birth (J:101385)
• premature closure of the coronal suture is first seen around E18.5 with more significant overlap between the osteogenic fronts developing over time and fewer mesenchymal cells are found in the coronal suture at birth (J:101385)
• development of the sagittal suture is slightly delayed (J:101385)
• development of the sagittal suture is slightly delayed (J:101385)
• significant shortening of the anterior-posterior axis (J:101385)
• significant shortening of the anterior-posterior axis (J:101385)
• calvarial bone formation is decreased (J:101385)
• calvarial bone formation is decreased (J:101385)
• the frontal bone is thinner and at P1 and P8 increased apoptosis is seen (J:101385)
• the frontal bone is thinner and at P1 and P8 increased apoptosis is seen (J:101385)
• the parietal bone is thinner and at P1 and P8 increased apoptosis is seen (J:101385)
• the parietal bone is thinner and at P1 and P8 increased apoptosis is seen (J:101385)
• the presphenoid bone is significantly shorter (J:101385)
• the presphenoid bone is significantly shorter (J:101385)
• after P10 some mutants have slightly shorter columns of proliferating chondrocytes (J:101385)
• after P10 some mutants have slightly shorter columns of proliferating chondrocytes (J:101385)
• craniosynostosis is most pronounced in the coronal suture (J:101385)
• craniosynostosis is most pronounced in the coronal suture (J:101385)

vision/eye

reproductive system
• all surviving females are sterile (J:101385)
• all surviving females are sterile (J:101385)
• only 1 male generated 2 litters when mated with a wild-type female (J:101385)
• only 1 male generated 2 litters when mated with a wild-type female (J:101385)

craniofacial
• cranial abnormalities vary in severity and the severely affected mutants die postnatally (J:101385)
• cranial abnormalities vary in severity and the severely affected mutants die postnatally (J:101385)
• some adults have asymmetrical skulls; however no obvious hand/foot abnormalities are seen (J:101385)
• some adults have asymmetrical skulls; however no obvious hand/foot abnormalities are seen (J:101385)
• at P1 and P8 increased apoptosis is seen with the highest levels seen in the parietal and frontal bones; however no significant difference in osteoblast proliferation (at E16.5, E18.5, P1, P5, and P8) or differentiation (at E18.5, P1, and P18) is seen in the sutures (J:101385)
• at P1 and P8 increased apoptosis is seen with the highest levels seen in the parietal and frontal bones; however no significant difference in osteoblast proliferation (at E16.5, E18.5, P1, P5, and P8) or differentiation (at E18.5, P1, and P18) is seen in the sutures (J:101385)
• premature closure of the coronal suture is first seen around E18.5 with more significant overlap between the osteogenic fronts developing over time and fewer mesenchymal cells are found in the coronal suture at birth (J:101385)
• premature closure of the coronal suture is first seen around E18.5 with more significant overlap between the osteogenic fronts developing over time and fewer mesenchymal cells are found in the coronal suture at birth (J:101385)
• development of the sagittal suture is slightly delayed (J:101385)
• development of the sagittal suture is slightly delayed (J:101385)
• significant shortening of the anterior-posterior axis (J:101385)
• significant shortening of the anterior-posterior axis (J:101385)
• calvarial bone formation is decreased (J:101385)
• calvarial bone formation is decreased (J:101385)
• the frontal bone is thinner and at P1 and P8 increased apoptosis is seen (J:101385)
• the frontal bone is thinner and at P1 and P8 increased apoptosis is seen (J:101385)
• the parietal bone is thinner and at P1 and P8 increased apoptosis is seen (J:101385)
• the parietal bone is thinner and at P1 and P8 increased apoptosis is seen (J:101385)
• the presphenoid bone is significantly shorter (J:101385)
• the presphenoid bone is significantly shorter (J:101385)
• midface hypoplasia (J:101385)
• midface hypoplasia (J:101385)

embryogenesis
• severely affected mutants are very small compared to wild-type mice, less severely affected mutants are 70-80% of the size of wild-type littermates (J:101385)
• severely affected mutants are very small compared to wild-type mice, less severely affected mutants are 70-80% of the size of wild-type littermates (J:101385)

Mouse Models of Human Disease
OMIM ID Ref(s)
Apert Syndrome 101200 J:101385





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory