Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sil1Gt(RST462)Byg mutation
(0 available);
any
Sil1 mutation
(26 available)
|
|
|
nervous system
|
• at 10 weeks, Purkinje cells accumulate ubiquitin+ inclusions, a marker of endoplasmic reticulum stress
|
behavior/neurological
|
• at 3 and 4 months of age
|
|
• at 20 weeks, mice exhibit a wide stance compared with wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sil1Gt(RST462)Byg mutation
(0 available);
any
Sil1 mutation
(26 available)
|
|
|
behavior/neurological
|
• develop adult-onset ataxia
|
nervous system
|
• exhibit the same phenotype and pathology as homozygous Sil1wz mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sil1Gt(RST462)Byg mutation
(0 available);
any
Sil1 mutation
(26 available)
Sil1wz mutation
(1 available);
any
Sil1 mutation
(26 available)
|
|
|
behavior/neurological
|
• develop adult-onset ataxia
|
nervous system
|
• exhibit the same phenotype and pathology as homozygous Sil1wz mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm2.1Dron mutation
(1 available);
any
Ddit3 mutation
(20 available)
Sil1Gt(RST462)Byg mutation
(0 available);
any
Sil1 mutation
(26 available)
|
|
|
behavior/neurological
nervous system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hyou1tm1Oga mutation
(0 available);
any
Hyou1 mutation
(37 available)
Sil1Gt(RST462)Byg mutation
(0 available);
any
Sil1 mutation
(26 available)
|
|
|
nervous system
|
• at 6 to 8 weeks, Purkinje cells accumulate ubiquitin+ inclusions, a marker of endoplasmic reticulum stress
|
|
• at 4 and 6 weeks, Purkinje cells exhibit degeneration
• by 20 weeks most Purkinje cells have degenerated
• unlike Sil1Gt(RST462)Byg homozygotes, Purkinje cells in lobule X and caudal lobule IX degenerate by 3 months of age
|
behavior/neurological
|
• beginning at 2 months and extreme by 20 weeks
|
|
• at 10 weeks, mice exhibit a wide stance compared with wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc3tm8663Wcl mutation
(1 available);
any
Dnajc3 mutation
(25 available)
Sil1Gt(RST462)Byg mutation
(0 available);
any
Sil1 mutation
(26 available)
|
|
|
behavior/neurological
N |
• at 20 weeks, mice exhibit a normal rear stance width unlike Sil1Gt(RST462)Byg homozygotes
|
nervous system
|
• at 4 months of age, mice begin to exhibit Purkinje cell degeneration
• however, by 8 months most Purkinje cells remain intact and few Purkinje cells exhibit ubiquitin+ inclusions
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sil1Gt(RST462)Byg mutation
(0 available);
any
Sil1 mutation
(26 available)
Tg(CAG-HYOU1)8-8Yaoh mutation
(0 available)
|
|
|
behavior/neurological
N |
• unlike Sil1Gt(RST462)Byg homozygotes, mice do not exhibit ataxia
|
nervous system
N |
• unlike Sil1Gt(RST462)Byg homozygotes, mice up to 8 months of age do not exhibit Purkinje cell degeneration
|