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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sil1Gt(RST462)Byg
gene trap RST462, BayGenomics
MGI:3603007
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg B6.129P2-Sil1Gt(RST462)Byg MGI:4417863
hm2
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg involves: 129P2/OlaHsd * C57BL/6J MGI:3603319
ht3
Sil1Gt(RST462)Byg/Sil1wz involves: 129P2/OlaHsd * C57BL/6J * CXB5/ByJ MGI:3640087
cx4
Ddit3tm2.1Dron/Ddit3tm2.1Dron
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:4417867
cx5
Hyou1tm1Oga/Hyou1+
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J MGI:4417864
cx6
Dnajc3tm8663Wcl/Dnajc3tm8663Wcl
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J MGI:4417866
cx7
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Tg(CAG-HYOU1)8-8Yaoh/0
involves: 129P2/OlaHsd * C57BL/6J * ICR MGI:4417865


Genotype
MGI:4417863
hm1
Allelic
Composition
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic
Background
B6.129P2-Sil1Gt(RST462)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sil1Gt(RST462)Byg mutation (0 available); any Sil1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 10 weeks, Purkinje cells accumulate ubiquitin+ inclusions, a marker of endoplasmic reticulum stress

behavior/neurological
• at 3 and 4 months of age
• at 20 weeks, mice exhibit a wide stance compared with wild-type mice




Genotype
MGI:3603319
hm2
Allelic
Composition
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sil1Gt(RST462)Byg mutation (0 available); any Sil1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• develop adult-onset ataxia

nervous system
• exhibit the same phenotype and pathology as homozygous Sil1wz mice




Genotype
MGI:3640087
ht3
Allelic
Composition
Sil1Gt(RST462)Byg/Sil1wz
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CXB5/ByJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sil1Gt(RST462)Byg mutation (0 available); any Sil1 mutation (26 available)
Sil1wz mutation (1 available); any Sil1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• develop adult-onset ataxia

nervous system
• exhibit the same phenotype and pathology as homozygous Sil1wz mice




Genotype
MGI:4417867
cx4
Allelic
Composition
Ddit3tm2.1Dron/Ddit3tm2.1Dron
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm2.1Dron mutation (1 available); any Ddit3 mutation (20 available)
Sil1Gt(RST462)Byg mutation (0 available); any Sil1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• after 3 months

nervous system
• after 4 months




Genotype
MGI:4417864
cx5
Allelic
Composition
Hyou1tm1Oga/Hyou1+
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hyou1tm1Oga mutation (0 available); any Hyou1 mutation (37 available)
Sil1Gt(RST462)Byg mutation (0 available); any Sil1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 6 to 8 weeks, Purkinje cells accumulate ubiquitin+ inclusions, a marker of endoplasmic reticulum stress
• at 4 and 6 weeks, Purkinje cells exhibit degeneration
• by 20 weeks most Purkinje cells have degenerated
• unlike Sil1Gt(RST462)Byg homozygotes, Purkinje cells in lobule X and caudal lobule IX degenerate by 3 months of age

behavior/neurological
• beginning at 2 months and extreme by 20 weeks
• at 10 weeks, mice exhibit a wide stance compared with wild-type mice




Genotype
MGI:4417866
cx6
Allelic
Composition
Dnajc3tm8663Wcl/Dnajc3tm8663Wcl
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc3tm8663Wcl mutation (1 available); any Dnajc3 mutation (25 available)
Sil1Gt(RST462)Byg mutation (0 available); any Sil1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• at 20 weeks, mice exhibit a normal rear stance width unlike Sil1Gt(RST462)Byg homozygotes

nervous system
• at 4 months of age, mice begin to exhibit Purkinje cell degeneration
• however, by 8 months most Purkinje cells remain intact and few Purkinje cells exhibit ubiquitin+ inclusions




Genotype
MGI:4417865
cx7
Allelic
Composition
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Tg(CAG-HYOU1)8-8Yaoh/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sil1Gt(RST462)Byg mutation (0 available); any Sil1 mutation (26 available)
Tg(CAG-HYOU1)8-8Yaoh mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• unlike Sil1Gt(RST462)Byg homozygotes, mice do not exhibit ataxia

nervous system
N
• unlike Sil1Gt(RST462)Byg homozygotes, mice up to 8 months of age do not exhibit Purkinje cell degeneration





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory