Sil1^wz
Spontaneous Allele Detail

Summary

• Symbol: Sil1^wz
• Name: SIL1 nucleotide exchange factor; woozy
• MGI ID: MGI:3055918
• Gene: Sil1 Location: Chr18:35399449-35632443 bp, - strand Genetic Position: Chr18, 18.97 cM
• Alliance: Sil1^wz page

Mutation origin

• Strain of Origin: CXB5/ByJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: Mutant transcripts demonstrate splicing between exon 7 of Sil1 and an ETn retrotransposon inserted between position 4,799 and 4,800. The chimeric transcript has an in-frame stop codon after 96 nucleotides of ETn sequence. (J:100860)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sil1 Mutation: 26 strains or lines available

References

• Original: J:100860 Zhao L, et al., Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP. Nat Genet. 2005 Sep;37(9):974-9
• All: 5 reference(s)