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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Spry2tm1Ayos
targeted mutation 1, Akihiko Yoshimura
MGI:3584128
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Spry2tm1Ayos/Spry2tm1Ayos B6.Cg-Spry2tm1Ayos MGI:3584494
cx2
Spry2tm1Ayos/Spry2+
Spry4tm1Ayos/Spry4tm1Ayos
involves: 129 * C57BL/6J MGI:3700035
cx3
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4+
involves: 129 * C57BL/6J MGI:3700036
cx4
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4tm1Ayos
involves: 129 * C57BL/6J MGI:3700037


Genotype
MGI:3584494
hm1
Allelic
Composition
Spry2tm1Ayos/Spry2tm1Ayos
Genetic
Background
B6.Cg-Spry2tm1Ayos
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2tm1Ayos mutation (1 available); any Spry2 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about half die within 6 weeks after birth, with many of the remaining homozygotes surviving for at least 6 months

growth/size/body

digestive/alimentary system
• exhibit esophageal achalasia, showing a dilated esophagous that is clogged with saburra in 4 week or older mice
• intestinal gauge is partly dilated and filled with gas at 2 months of age
• contraction force of the lower esophageal sphincter in response to carbachol is more than 5 times stronger than in wild-type
• motility of the intestine in response to carbachol is abnormal
• intestinal pseudo-obstruction

nervous system
• enteric nervous system hyperplasia
• hypergangliosis of the enteric nervous system
• enteric nerve hyperplasia




Genotype
MGI:3700035
cx2
Allelic
Composition
Spry2tm1Ayos/Spry2+
Spry4tm1Ayos/Spry4tm1Ayos
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2tm1Ayos mutation (1 available); any Spry2 mutation (16 available)
Spry4tm1Ayos mutation (1 available); any Spry4 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are rarely born
• homozygotes that are born appear sick and most die within a few weeks of birth for unknown reasons

growth/size/body




Genotype
MGI:3700036
cx3
Allelic
Composition
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4+
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2tm1Ayos mutation (1 available); any Spry2 mutation (16 available)
Spry4tm1Ayos mutation (1 available); any Spry4 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3700037
cx4
Allelic
Composition
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4tm1Ayos
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2tm1Ayos mutation (1 available); any Spry2 mutation (16 available)
Spry4tm1Ayos mutation (1 available); any Spry4 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

vision/eye

craniofacial
• craniofacial abnormalities

limbs/digits/tail
• limb abnormalities

nervous system
• severe truncation of the forebrain and cephalic neural crest-derived head tissues
• alobar brain development and cyclopia resemble holoprosencephaly

respiratory system
• exhibit abnormalities of the lung pattern and epithelial branching

Mouse Models of Human Disease
OMIM ID Ref(s)
Apert Syndrome 101200 J:116506





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory