Phenotypes associated with this allele

• Allele Symbol: Ptk2b^tm1Schl
• Allele Name: targeted mutation 1, Joseph Schlessinger
• Allele ID: MGI:3583796
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptk2b^tm1Schl/Ptk2b^tm1Schl	involves: 129S1/Sv * 129X1/SvJ	MGI:3584536

Genotype
MGI:3584536

hm1

• Allelic Composition: Ptk2b^tm1Schl/Ptk2b^tm1Schl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:99741 )

• homozygous macrophages do not show an obvious increase in Ca²⁺ concentration after chemokine stimulation unlike wild-type macrophages

impaired macrophage chemotaxis ( J:99741 )

• inflammation in response to subcutaneous carrageenan stimulation is reduced and only 20% of the cells in the infiltrate are macrophages compared to 70% in wild-type mice

decreased acute inflammation ( J:99741 )

• inflammation in response to subcutaneous carrageenan stimulation is reduced with only 2.8 x 10⁶ cells per injected area compared to 4.8 x 10⁶ cells per injected area in wild-type mice

cellular

impaired macrophage chemotaxis ( J:99741 )

• inflammation in response to subcutaneous carrageenan stimulation is reduced and only 20% of the cells in the infiltrate are macrophages compared to 70% in wild-type mice

hematopoietic system

abnormal macrophage physiology ( J:99741 )

• homozygous macrophages do not show an obvious increase in Ca²⁺ concentration after chemokine stimulation unlike wild-type macrophages

impaired macrophage chemotaxis ( J:99741 )

• inflammation in response to subcutaneous carrageenan stimulation is reduced and only 20% of the cells in the infiltrate are macrophages compared to 70% in wild-type mice