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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Psen1tm1Tak
targeted mutation 1, Junji Takeda
MGI:3583662
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Psen1tm1Tak/Psen1tm1Tak involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3589555
ht2
Psen1tm1Tak/Psen1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5795582


Genotype
MGI:3589555
hm1
Allelic
Composition
Psen1tm1Tak/Psen1tm1Tak
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Tak mutation (0 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• during place learning in a Morris water maze homozygotes have increased quadrant entries and escape latencies compared to wild-type mice; however motor coordination and swimming ability are not impaired and performance in the probe trial is normal
• homozygotes are more likely than wild-type mice to display whole-body startle following an auditory stimulus
• homozygotes display a tighter grip response on a horizontal grid

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:99353




Genotype
MGI:5795582
ht2
Allelic
Composition
Psen1tm1Tak/Psen1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Tak mutation (0 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice show increased levels of amyloid beta(1-42) peptide, however amyloid beta fails to deposit in the brains
• some hippocampal neurons exhibit Congo red birefringence and Thioflavin T reactivity, indicating neurofibrillary tangles
• mice exhibit formation of tau inclusions starting at 7 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:108326





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory