Mouse Genome Informatics
hm1
    Psen1tm1Tak/Psen1tm1Tak
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• during place learning in a Morris water maze homozygotes have increased quadrant entries and escape latencies compared to wild-type mice; however motor coordination and swimming ability are not impaired and performance in the probe trial is normal
• homozygotes are more likely than wild-type mice to display whole-body startle following an auditory stimulus
• homozygotes display a tighter grip response on a horizontal grid

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:99353