Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crkltm1Hkp mutation
(1 available);
any
Crkl mutation
(15 available)
Tg(BCR/ABL)623Hkp mutation
(2 available)
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mortality/aging
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• average survival is 158 days
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neoplasm
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• develop B-lineage leukemia to the same extent as mice expressing the transgene alone
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• develop B-lineage lymphoma to the same extent as mice expressing the transgene alone
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf1tm1Kast mutation
(0 available);
any
Ikzf1 mutation
(30 available)
Tg(BCR/ABL)623Hkp mutation
(2 available)
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neoplasm
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• mice develop B cell acute lymphoblastic leukemia with a median latency of 5.7 weeks
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac3tm1Hkp mutation
(1 available);
any
Rac3 mutation
(13 available)
Tg(BCR/ABL)623Hkp mutation
(2 available)
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mortality/aging
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• mean life span for females is 321 +/- 59 days significantly longer than females wild-type for Rac3 (193 +/- 29 days); however, mean life span for males is not significantly different from males wild-type for Rac3
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neoplasm
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• mutants develop B-lineage lymphoblastic leukemia
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Allelic Composition |
Tg(BCR/ABL)623Hkp/0
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Genetic Background |
involves: C57BL/6 * C57BL/6J * CBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCR/ABL)623Hkp mutation
(2 available)
|
|
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mortality/aging
|
• mean life span for females is 193 +/- 29 days significantly shorter than females homozygous for Rac3tm1Hkp (321 +/- 59 days); however, mean life span for males is not significantly different
|
neoplasm
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• mutants develop B-lineage lymphoblastic leukemia
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCR/ABL)623Hkp mutation
(2 available)
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|
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neoplasm
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• mice develop B cell acute lymphoblastic leukemia with a median latency of 14.7 weeks
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Allelic Composition |
Tg(BCR/ABL)623Hkp/?
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCR/ABL)623Hkp mutation
(2 available)
|
|
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mortality/aging
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• average survival is 200 days
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neoplasm
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• develop B-lineage leukemia
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• develop B-lineage lymphoma
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