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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(BCR/ABL)623Hkp
transgene insertion 623, Nora Heisterkamp
MGI:3582388
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Crkltm1Hkp/Crkltm1Hkp
Tg(BCR/ABL)623Hkp/?
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA MGI:3723274
cx2
Ikzf1tm1Kast/Ikzf1+
Tg(BCR/ABL)623Hkp/0
involves: 129S2/SvPas * C57BL/6 * CBA MGI:4819230
cx3
Rac3tm1Hkp/Rac3tm1Hkp
Tg(BCR/ABL)623Hkp/0
involves: C57BL/6 * C57BL/6J * CBA MGI:3582413
tg4
Tg(BCR/ABL)623Hkp/0 involves: C57BL/6 * C57BL/6J * CBA MGI:3582414
tg5
Tg(BCR/ABL)623Hkp/0 involves: C57BL/6 * CBA MGI:3582403
tg6
Tg(BCR/ABL)623Hkp/? involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA MGI:3723282


Genotype
MGI:3723274
cx1
Allelic
Composition
Crkltm1Hkp/Crkltm1Hkp
Tg(BCR/ABL)623Hkp/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crkltm1Hkp mutation (1 available); any Crkl mutation (5 available)
Tg(BCR/ABL)623Hkp mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average survival is 158 days

neoplasm
• develop B-lineage leukemia to the same extent as mice expressing the transgene alone
• develop B-lineage lymphoma to the same extent as mice expressing the transgene alone




Genotype
MGI:4819230
cx2
Allelic
Composition
Ikzf1tm1Kast/Ikzf1+
Tg(BCR/ABL)623Hkp/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf1tm1Kast mutation (0 available); any Ikzf1 mutation (5 available)
Tg(BCR/ABL)623Hkp mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop B cell acute lymphoblastic leukemia with a median latency of 5.7 weeks

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute lymphocytic leukemia DOID:9952 OMIM:247640
OMIM:613065
OMIM:613067
OMIM:615545
J:160846




Genotype
MGI:3582413
cx3
Allelic
Composition
Rac3tm1Hkp/Rac3tm1Hkp
Tg(BCR/ABL)623Hkp/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac3tm1Hkp mutation (1 available); any Rac3 mutation (10 available)
Tg(BCR/ABL)623Hkp mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean life span for females is 321 +/- 59 days significantly longer than females wild-type for Rac3 (193 +/- 29 days); however, mean life span for males is not significantly different from males wild-type for Rac3

neoplasm
• mutants develop B-lineage lymphoblastic leukemia




Genotype
MGI:3582414
tg4
Allelic
Composition
Tg(BCR/ABL)623Hkp/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCR/ABL)623Hkp mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean life span for females is 193 +/- 29 days significantly shorter than females homozygous for Rac3tm1Hkp (321 +/- 59 days); however, mean life span for males is not significantly different

neoplasm
• mutants develop B-lineage lymphoblastic leukemia




Genotype
MGI:3582403
tg5
Allelic
Composition
Tg(BCR/ABL)623Hkp/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCR/ABL)623Hkp mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• pre-B cell leukemia
• mice develop B cell acute lymphoblastic leukemia with a median latency of 14.7 weeks




Genotype
MGI:3723282
tg6
Allelic
Composition
Tg(BCR/ABL)623Hkp/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCR/ABL)623Hkp mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average survival is 200 days

neoplasm
• develop B-lineage leukemia
• develop B-lineage lymphoma





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory