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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abcc3tm1Bor
targeted mutation 1, Piet Borst
MGI:3582301
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Abcc3tm1Bor/Abcc3tm1Bor FVB.129P2-Abcc3tm1Bor MGI:3582596
hm2
Abcc3tm1Bor/Abcc3tm1Bor involves: 129P2/Ola * FVB/N MGI:3582595


Genotype
MGI:3582596
hm1
Allelic
Composition
Abcc3tm1Bor/Abcc3tm1Bor
Genetic
Background
FVB.129P2-Abcc3tm1Bor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc3tm1Bor mutation (0 available); any Abcc3 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• plasma levels of M6G (a metabolite of morphine seen in humans) are lower 60 minutes after M6G injection and the antinociceptive effect of M6G is decreased in homozygotes

behavior/neurological
• the antinociceptive effect of M6G is decreased




Genotype
MGI:3582595
hm2
Allelic
Composition
Abcc3tm1Bor/Abcc3tm1Bor
Genetic
Background
involves: 129P2/Ola * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc3tm1Bor mutation (0 available); any Abcc3 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit a minor decrease in uptake of bile salts from the gut and consequently fecal bile salt excretion compared with wild-type mice
• plasma and brain levels and urinary excretion of M3G (metabolite of morphine) are significantly lower 30 minutes after morphine injection compared to wild-type mice
• hepatic and biliary levels of M3G are increased and excretion pathway of morphine and M3G is shifted from the urinary to gastrointestinal
• after injection of M3G, plasma levels of M3G are lower and detectable levels are morphine are seen in the plasma unlike in wild-type mice





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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory