Phenotypes associated with this allele

• Allele Symbol: Abcc3^tm1Bor
• Allele Name: targeted mutation 1, Piet Borst
• Allele ID: MGI:3582301
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcc3^tm1Bor/Abcc3^tm1Bor	FVB.129P2-Abcc3^tm1Bor	MGI:3582596
hm2	Abcc3^tm1Bor/Abcc3^tm1Bor	involves: 129P2/Ola * FVB/N	MGI:3582595

Genotype
MGI:3582596

hm1

• Allelic Composition: Abcc3^tm1Bor/Abcc3^tm1Bor
• Genetic Background: FVB.129P2-Abcc3^tm1Bor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:99234 )

• plasma levels of M6G (a metabolite of morphine seen in humans) are lower 60 minutes after M6G injection and the antinociceptive effect of M6G is decreased in homozygotes

behavior/neurological

decreased chemically-elicited antinociception ( J:99234 )

• the antinociceptive effect of M6G is decreased

Genotype
MGI:3582595

hm2

• Allelic Composition: Abcc3^tm1Bor/Abcc3^tm1Bor
• Genetic Background: involves: 129P2/Ola * FVB/N

homeostasis/metabolism

abnormal bile salt homeostasis ( J:149653 )

• mice exhibit a minor decrease in uptake of bile salts from the gut and consequently fecal bile salt excretion compared with wild-type mice

abnormal xenobiotic pharmacokinetics ( J:99234 )

• plasma and brain levels and urinary excretion of M3G (metabolite of morphine) are significantly lower 30 minutes after morphine injection compared to wild-type mice

• hepatic and biliary levels of M3G are increased and excretion pathway of morphine and M3G is shifted from the urinary to gastrointestinal

• after injection of M3G, plasma levels of M3G are lower and detectable levels are morphine are seen in the plasma unlike in wild-type mice