Phenotypes associated with this allele

• Allele Symbol: Fes^tm2Pag
• Allele Name: targeted mutation 2, Peter A Greer
• Allele ID: MGI:3578748
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fes^tm2Pag/Fes^tm2Pag	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3581864
cx2	Fes^tm2Pag/Fes^tm2Pag Tg(MMTV-PyVT)634Mul/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3581866

Genotype
MGI:3581864

hm1

• Allelic Composition: Fes^tm2Pag/Fes^tm2Pag
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased pro-B cell number ( J:98590 )

• increased numbers of pro-B cells are seen in the bone marrow and spleen

abnormal myelopoiesis ( J:98590 )

• a significant decrease in the Ly6-G+ CD11b+ population is seen

decreased B cell number ( J:98590 )

• decreased in the spleen but not in the bone marrow

increased pre-B cell number ( J:98590 )

• increased numbers of pre-B cells are seen in the bone marrow and spleen

increased susceptibility to endotoxin shock ( J:98590 )

• homozygous males but not females are significantly more susceptible to LPS-induced lethality compared to sex-matched wild-type mice

hematopoietic system

increased pro-B cell number ( J:98590 )

• increased numbers of pro-B cells are seen in the bone marrow and spleen

abnormal myelopoiesis ( J:98590 )

• a significant decrease in the Ly6-G+ CD11b+ population is seen

increased erythrocyte cell number ( J:98590 )

• a 5% increase in the number of red blood cells is seen; however, erythropoiesis appears normal

increased hematocrit ( J:98590 )

• a 5% increase in the hematocrit is seen

increased hemoglobin content ( J:98590 )

• a 5% increase in hemoglobin concentration is seen

decreased B cell number ( J:98590 )

• decreased in the spleen but not in the bone marrow

increased pre-B cell number ( J:98590 )

• increased numbers of pre-B cells are seen in the bone marrow and spleen

reproductive system

increased litter size ( J:98590 )

• litter size is slightly but significantly increased in crosses involving a homozygote and either a homozygous or heterozygous partner

Genotype
MGI:3581866

cx2

• Allelic Composition: Fes^tm2Pag/Fes^tm2Pag; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

neoplasm

decreased tumor latency ( J:98281 )

• tumor onset and initiation of the rapid growth phase of tumor development occur earlier compared to transgenic mice that are wild-type for Fes or homozygous for Fes^tm1Pag