All Phenotypes Celsr3<tm1Agof> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Celsr3^tm1Agof/Celsr3^tm1Agof	either: CD-1.129P2-Celsr3^tm1Agof or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)	MGI:3579160
cn2	Celsr3^tm1Agof/Celsr3^tm2Agof Tg(Nkx2-1-cre)1Wdr/0	involves: 129P2/OlaHsd	MGI:3795745
cn3	Celsr3^tm1Agof/Celsr3^tm2Agof Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd	MGI:3795739
cn4	Celsr3^tm1Agof/Celsr3^tm2Agof Emx1^tm1(cre)Krj/Emx1⁺	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3795740
cn5	Celsr3^tm1Agof/Celsr3^tm2Agof Tg(Gsx2-icre)1Kess/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3795744
cn6	Celsr3^tm1Agof/Celsr3^tm2Agof Tg(Gsx2-icre)1Kess/0 Tg(Nkx2-1-cre)1Wdr/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3795746
cn7	Celsr3^tm1Agof/Celsr3^tm2Agof Tg(mI56i-cre,EGFP)1Kc/0	involves: 129P2/OlaHsd * FVB/N	MGI:3795743

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:98367 )

• died a few hours after birth

nervous system

abnormal axon guidance ( J:98367 )

• abnormal development of the corticosubcortical, thalamocortical, corticospinal and spinocerebellar tracts and several longitudinal bundles in the hindbrain and spinal cord

• fiber bundles did not cross the striatum

• a large aberrant tract originated from the thalamus (the thalamic bundle), however instead of making a sharp turn toward the internal capsule, it descended laterally to the hypothalamic region and turned around the basal forebrain to cross the tissue and enter the cortical marginal zone

abnormal brain morphology ( J:98367 )

• absent medial lemniscus, and the globular striatum protruded excessively into a moderately enlarged ventricle

abnormal cortical marginal zone morphology ( J:98367 )

• observed swollen, moderately osmiophilic processes in the cortical marginal zone

absent brain internal capsule ( J:98367 )

abnormal globus pallidus morphology ( J:98367 )

• the pallidum had a rounded shape

abnormal cerebral cortex morphology ( J:98367 )

• abnormally thin cortical wall, mostly because of hypotrophy of the intermediate zone

• reduction of fibers in the cortical intermediate zone and abnormal small radial fascicles in the upper cortical tier

abnormal nervous system tract morphology ( J:98367 )

• the posterior spinocerebellar tract appeared dissociated and many longitudinal fiber bundles in the hindbrain tegmentum and dorsal spinal cord were reduced in size, poorly fasciculated or both

absent anterior commissure ( J:98367 )

decreased corticospinal tract size ( J:98367 )

• smaller corticospinal tract

respiratory system

abnormal pulmonary alveolus morphology ( J:98367 )

• reduced alveolar space, however all other components of lung tissue were normal

atelectasis ( J:98367 )

• poorly inflated lungs, although lobular pattern was normal

respiratory failure ( J:98367 )

• die of central ventilation failure

digestive/alimentary system

distended duodenum ( J:98367 )

• exhibited air dilation of the duodenum

meteorism ( J:98367 )

• exhibited air dilation of the stomach

homeostasis/metabolism

cyanosis ( J:98367 )

• newborns exhibited progressive cyanosis

behavior/neurological

impaired coordination ( J:98367 )

• newborns exhibited poorly coordinated movements

growth/size/body

meteorism ( J:98367 )

• exhibited air dilation of the stomach

cellular

abnormal axon guidance ( J:98367 )

• abnormal development of the corticosubcortical, thalamocortical, corticospinal and spinocerebellar tracts and several longitudinal bundles in the hindbrain and spinal cord

• fiber bundles did not cross the striatum

Allelic Composition	Celsr3^tm1Agof/Celsr3^tm2Agof Tg(Nkx2-1-cre)1Wdr/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3^tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3^tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Tg(Nkx2-1-cre)1Wdr mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:134879 )

N	• the brain internal capsule develops normally

Allelic Composition	Celsr3^tm1Agof/Celsr3^tm2Agof Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent anterior commissure ( J:134879 )

abnormal brain internal capsule morphology ( J:134879 )

• despite normal expression in the dorsal thalamus, the three components of the internal capsule (corticothalamic axons, thalamocortical axons and subcerebral projections) are abnormal

• unlike in control mice, no thalamic fibers turn towards the striatum

• however, corticothalamic axons grow towards the ventral telencephalon

abnormal corticospinal tract morphology ( J:134879 )

Allelic Composition	Celsr3^tm1Agof/Celsr3^tm2Agof Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal anterior commissure morphology ( J:134879 )

• only diminutive bundles originating from the olfactory nuclei run caudally and turn but never cross the midline unlike in control mice (double heterozygotes)

abnormal brain internal capsule morphology ( J:134879 )

• subdural projections develop abnormally

• however, corticothalamic and thalamicortical axons are normal

abnormal corticospinal tract morphology ( J:134879 )

Allelic Composition	Celsr3^tm1Agof/Celsr3^tm2Agof Tg(Gsx2-icre)1Kess/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:134879 )

N	• the brain internal capsule develops normally

Allelic Composition	Celsr3^tm1Agof/Celsr3^tm2Agof Tg(Gsx2-icre)1Kess/0 Tg(Nkx2-1-cre)1Wdr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:134879 )

N	• the brain internal capsule develops normally

Allelic Composition	Celsr3^tm1Agof/Celsr3^tm2Agof Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain internal capsule morphology ( J:134879 )

• the thalamocortical axons aberrantly run through the pallidum and amygdala

• while corticofugal fibers cross the pallial-subpallial boundary and enter the lateral part of the basal forebrain, they fail to progress and spiral in a disordered manner

• both corticothalamic and thalamocortial axons are abnormal

abnormal corticospinal tract morphology ( J:134879 )

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