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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sema4atm1Kik
targeted mutation 1, Hutoshi Kikutani
MGI:3575087
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sema4atm1Kik/Sema4atm1Kik either: B6.Cg-Sema4atm1Kik or C.Cg-Sema4atm1Kik MGI:3575442
hm2
 		Sema4atm1Kik/Sema4atm1Kik Not Specified MGI:3706339
cx3
 		Sema4atm1Kik/Sema4atm1Kik
Sema4dtm1Kik/Sema4dtm1Kik 		involves: 129P2/OlaHsd MGI:3706317


Genotype
MGI:3575442
hm1
Allelic
Composition		 Sema4atm1Kik/Sema4atm1Kik
Genetic
Background		 either: B6.Cg-Sema4atm1Kik or C.Cg-Sema4atm1Kik
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4atm1Kik mutation (0 available); any Sema4a mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T-helper 1 cell differentiation ( J:97027 )
• T helper 1 cells differentiated poorly in an in vitro assay
abnormal CD4-positive, alpha-beta T cell physiology ( J:97027 )
• in vivo antigen-specific T cell priming and antibody responses against T cell-dependent antigens are impaired

immune system
abnormal T-helper 1 cell differentiation ( J:97027 )
• T helper 1 cells differentiated poorly in an in vitro assay
abnormal CD4-positive, alpha-beta T cell physiology ( J:97027 )
• in vivo antigen-specific T cell priming and antibody responses against T cell-dependent antigens are impaired
abnormal dendritic cell antigen presentation ( J:97027 )
• dendritic cells from mutant poorly stimulated allogenic T cells
decreased susceptibility to type IV hypersensitivity reaction ( J:97027 )
• delayed type hypersensitivity reactions are impaired
abnormal cytokine secretion ( J:97027 )
• production of IFNG by Th1-conditioned cells is reduced
• antigen-induced IL-4 production by CD4+ T cells is increased but IFNG production is decreased




Genotype
MGI:3706339
hm2
Allelic
Composition		 Sema4atm1Kik/Sema4atm1Kik
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4atm1Kik mutation (0 available); any Sema4a mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
increased retina apoptosis ( J:119485 )
• increased in the outer nuclear layer

cellular
increased retina apoptosis ( J:119485 )
• increased in the outer nuclear layer

nervous system




Genotype
MGI:3706317
cx3
Allelic
Composition		 Sema4atm1Kik/Sema4atm1Kik
Sema4dtm1Kik/Sema4dtm1Kik
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4atm1Kik mutation (0 available); any Sema4a mutation (39 available)
Sema4dtm1Kik mutation (2 available); any Sema4d mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:119485 )
N
• neither defects in the cerebellum nor ectopic granule cells are observed despite being possible ligands for Plxnb2




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory