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Allele Symbol Allele Name Allele ID |
Atf3tm1Dron targeted mutation 1, David Ron MGI:3531501 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• primary islets are partially protected against IL1B- IFNG- and NO donor-induced apoptosis but not significantly protected when 3 cytokines or 2 cytokines plus FAS are used to induce apoptosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in an induced asthma model, levels of antigen-specific IgG2a are reduced more than 7-fold compared to wild-type controls
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• there is increased production of Th2-associated cytokines (IL-4, IL-5, IL-13) in vitro from T cells isolated from BAL fluid from mice induced to have asthma
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• in an induced asthma model, about five times as much IL-13 is secreted into the BAL fluid as in wild-type controls one day after the last antigen challenge
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• in an induced asthma model, about twice as much IL-4 is secreted into the BAL fluid as in wild-type controls one day after the last antigen challenge
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• in an induced asthma model, about twice as much IL-5 is secreted into the BAL fluid as in wild-type controls one day after the last antigen challenge
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• airway resistance is significantly increased in an induced asthma model when compared with their WT counterparts
• resistance is over 3-fold greater than in wild-type
• increased resistance is accompanied by more than a 2-fold increase in inflammatory cells in the bronchoalveolar lavage (BAL) fluid compared to wild-type mice in the same disease model
• differential counts show a significantly higher number of macrophages, lymphocytes, and eosinophils in the BAL fluid in this asthma model
• goblet cell hyperplasia and mucous hypersecretion are more pronounced in this asthma model than in wild-type mice
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• airway resistance is significantly increased in an induced asthma model when compared with their WT counterparts
• resistance is over 3-fold greater than in wild-type
• increased resistance is accompanied by more than a 2-fold increase in inflammatory cells in the bronchoalveolar lavage (BAL) fluid compared to wild-type mice in the same disease model
• differential counts show a significantly higher number of macrophages, lymphocytes, and eosinophils in the BAL fluid in this asthma model
• goblet cell hyperplasia and mucous hypersecretion are more pronounced in this asthma model than in wild-type mice
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• injected tumors metastasize less efficiently than in wild-type mice
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• in an induced asthma model, levels of antigen-specific IgG2a are reduced more than 7-fold compared to wild-type controls
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• there is increased production of Th2-associated cytokines (IL-4, IL-5, IL-13) in vitro from T cells isolated from BAL fluid from mice induced to have asthma
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced lung metastasis compared to in Tg(MMTV-PyVT)634Mul mice
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• reduced primary tumor volume compared to in Tg(MMTV-PyVT)634Mul mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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