Phenotypes associated with this allele

• Allele Symbol: Cckar^tm1Kym
• Allele Name: targeted mutation 1, Kyoko Miyasaka
• Allele ID: MGI:3529601
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cckar^tm1Kym/Cckar^tm1Kym	B6.129S4-Cckar^tm1Kym	MGI:3530247
hm2	Cckar^tm1Kym/Cckar^tm1Kym	involves: 129S4/SvJae	MGI:4821004
hm3	Cckar^tm1Kym/Cckar^tm1Kym	involves: 129S4/SvJae * C57BL/6J	MGI:3530244
cx4	Cckar^tm1Kym/Cckar^tm1Kym Cckbr^tm1Tom/Cckbr^tm1Tom	B6.129S4-Cckar^tm1Kym Cckbr^tm1Tom	MGI:4821093
cx5	Cckar^tm1Kym/Cckar^tm1Kym Cckbr^tm1Tom/Cckbr^tm1Tom	involves: 129S4/SvJae	MGI:4821005
cx6	Cckar^tm1Kym/Cckar^tm1Kym Cckbr^tm1Tom/Cckbr^tm1Tom	involves: 129S4/SvJae * C57BL/6J	MGI:3530257

Genotype
MGI:3530247

hm1

• Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym
• Genetic Background: B6.129S4-Cckar^tm1Kym

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal body temperature homeostasis ( J:95791 )

• regulation of the core body temperature to changes in ambient temperature was disrupted compared to wild-type or homozygous Cckbr mutants, however the circadian rhythm of body temperature was normal

behavior/neurological

hyperactivity ( J:107934 )

• mice more entries into open arms than wild-type mice and Cckbr^tm1Tom homozygotes

• however, the number of entries into enclosed arms is normal

Genotype
MGI:4821004

hm2

• Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym
• Genetic Background: involves: 129S4/SvJae

behavior/neurological

behavior/neurological phenotype ( J:96087 )

N • mice exhibit normal food intake

growth/size/body

growth/size/body region phenotype ( J:96087 )

N • mice exhibit normal weight

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:96087 )

N • mice exhibit normal energy expenditure

digestive/alimentary system

digestive/alimentary phenotype ( J:101985 )

N

Genotype
MGI:3530244

hm3

• Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

endocrine/exocrine glands

abnormal pancreas secretion ( J:96137 )

• did not observe amylase secretion from dispersed acini in response to stimulation with the neuropeptide, CCK-8, however response to neuromedin C and carbachol was similar as in controls

• CCK-8 administration to homozygotes with ligation of the cystic duct and pylorus to exclude the involvement of gallbladder contraction and of gastric acid did not increase bile-pancreatic juice flow, amylase output or bicarbonate output as it did in controls, however response to acetylcholine and neuromedin C was similar as in controls

• no differences were observed in pancreatic wet weight/body weight and the protein, amylase, and chymotrypsin contents in the pancreas under normal conditions and glucose tolerance was normal in homozygotes

Genotype
MGI:4821093

cx4

• Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym; Cckbr^tm1Tom/Cckbr^tm1Tom
• Genetic Background: B6.129S4-Cckar^tm1Kym Cckbr^tm1Tom

behavior/neurological

abnormal behavior ( J:107934 )

• mice spend more time in enclosed arms than wild-type mice

growth/size/body

decreased body weight ( J:107934 )

Genotype
MGI:4821005

cx5

• Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym; Cckbr^tm1Tom/Cckbr^tm1Tom
• Genetic Background: involves: 129S4/SvJae

growth/size/body

increased pancreas weight ( J:96087 )

decreased body weight ( J:96087 , J:101985 )

• at one measurement, mice weighed significantly less than wild-type mice (J:96087)

• however, no signifiance was detected in body weight at a different measurement (J:96087)

increased kidney weight ( J:96087 )

digestive/alimentary system

impaired gastric peristalsis ( J:101985 )

• mice exhibit delayed gastric emptying compared with wild-type mice that is not affected by treatment with CCK-8S unlike in wild-type mice

• mice treated with 5 mg/kg atropine exhibit delayed gastric emptying compared with similarly treated Cckar^tm1Kym homozygotes

homeostasis/metabolism

increased energy expenditure ( J:96087 )

behavior/neurological

abnormal eating behavior ( J:96087 )

endocrine/exocrine glands

increased pancreas weight ( J:96087 )

renal/urinary system

increased kidney weight ( J:96087 )

Genotype
MGI:3530257

cx6

• Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym; Cckbr^tm1Tom/Cckbr^tm1Tom
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

growth/size/body

decreased body weight ( J:95791 )

• double homozygous mutants weighed significantly less than single homozygous or wildtype mice

homeostasis/metabolism

abnormal body temperature homeostasis ( J:95791 )

• regulation of the core body temperature to changes in ambient temperature was disrupted compared to wild-type or homozygous Cckbr mutants, however the circadian rhythm of body temperature was normal