Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs11tm1Lex mutation
(2 available);
any
Rgs11 mutation
(31 available)
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vision/eye
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• the leading and trailing edges for the average b-wave response from the cone-isolated b-wave is delayed and the amplitude is increased compared to in wild-type mice
• photopic b-wave electroretinogram responses are delayed compared to in wild-type mice
• however, photoreceptor-derived a-waves are normal
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• scotopic b-wave electroretinogram responses are delayed compared to in wild-type mice
• negative- and positive-scotopic threshold responses are reduced compared to in wild-type mice
• however, photoreceptor-derived a-waves are normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs11tm1Lex mutation
(2 available);
any
Rgs11 mutation
(31 available)
Rgs7tm1Cjch mutation
(0 available);
any
Rgs7 mutation
(26 available)
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Rgs7tm1Cjch/Rgs7tm1Cjch Rgs11tm1Lex/Rgs11tm1Lex mice have no ERG b-waves and contain ultrastructural defects in the retinal outer plexiform layer
mortality/aging
reproductive system
vision/eye
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• fewer triads per spherule compared to in wild-type mice
• fewer spherules with ribbons compared to in wild-type mice
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• absent b-wave under scotopic and photopic conditions
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• absent b-wave under scotopic and photopic conditions
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs11tm1Lex mutation
(2 available);
any
Rgs11 mutation
(31 available)
Rgs7tm1.1Kama mutation
(0 available);
any
Rgs7 mutation
(26 available)
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vision/eye
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• mice lack dark-adapted electroretinogram b-wave
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nervous system
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• rod ON bipolar cells lack a flash response and exhibit a 40-folder shorter light-evoked response compared with wild-type cells
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vision/eye
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• mice exhibit additive effects on time course of the dark-adapted electroretinogram responses arising from bipolar cells
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• negative-scotopic threshold response is reduced compared to in wild-type mice or single mutants
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