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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rgs11tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528953
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rgs11tm1Lex/Rgs11tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609693
cx2
Rgs11tm1Lex/Rgs11tm1Lex
Rgs7tm1Cjch/Rgs7tm1Cjch
involves: 129S5/SvEvBrd * C57BL/6 MGI:5426907
cx3
Rgs11tm1Lex/Rgs11tm1Lex
Rgs7tm1.1Kama/Rgs7tm1.1Kama
involves: 129S5/SvEvBrd * C57BL/6 * FVB/N * SJL MGI:5427735
cx4
Rgs11tm1Lex/Rgs11tm1Lex
Rgs7tm1Lex/Rgs7tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J MGI:3850242


Genotype
MGI:3609693
hm1
Allelic
Composition
Rgs11tm1Lex/Rgs11tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs11tm1Lex mutation (2 available); any Rgs11 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the leading and trailing edges for the average b-wave response from the cone-isolated b-wave is delayed and the amplitude is increased compared to in wild-type mice
• photopic b-wave electroretinogram responses are delayed compared to in wild-type mice
• however, photoreceptor-derived a-waves are normal
• scotopic b-wave electroretinogram responses are delayed compared to in wild-type mice
• negative- and positive-scotopic threshold responses are reduced compared to in wild-type mice
• however, photoreceptor-derived a-waves are normal




Genotype
MGI:5426907
cx2
Allelic
Composition
Rgs11tm1Lex/Rgs11tm1Lex
Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs11tm1Lex mutation (2 available); any Rgs11 mutation (19 available)
Rgs7tm1Cjch mutation (0 available); any Rgs7 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Rgs7tm1Cjch/Rgs7tm1Cjch Rgs11tm1Lex/Rgs11tm1Lex mice have no ERG b-waves and contain ultrastructural defects in the retinal outer plexiform layer

mortality/aging
N
• normal viability

reproductive system
N
• normal fertility

vision/eye
• fewer triads per spherule compared to in wild-type mice
• fewer spherules with ribbons compared to in wild-type mice
• absent b-wave under scotopic and photopic conditions
• absent b-wave under scotopic and photopic conditions




Genotype
MGI:5427735
cx3
Allelic
Composition
Rgs11tm1Lex/Rgs11tm1Lex
Rgs7tm1.1Kama/Rgs7tm1.1Kama
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs11tm1Lex mutation (2 available); any Rgs11 mutation (19 available)
Rgs7tm1.1Kama mutation (0 available); any Rgs7 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice lack dark-adapted electroretinogram b-wave

nervous system
• rod ON bipolar cells lack a flash response and exhibit a 40-folder shorter light-evoked response compared with wild-type cells




Genotype
MGI:3850242
cx4
Allelic
Composition
Rgs11tm1Lex/Rgs11tm1Lex
Rgs7tm1Lex/Rgs7tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs11tm1Lex mutation (2 available); any Rgs11 mutation (19 available)
Rgs7tm1Lex mutation (2 available); any Rgs7 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice exhibit additive effects on time course of the dark-adapted electroretinogram responses arising from bipolar cells
• negative-scotopic threshold response is reduced compared to in wild-type mice or single mutants





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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory