Rgs7^tm1.1Kama
Targeted Allele Detail

Summary

• Symbol: Rgs7^tm1.1Kama
• Name: regulator of G protein signaling 7; targeted mutation 1.1, Kirill Martemyanov
• MGI ID: MGI:5427707
• Gene: Rgs7 Location: Chr1:174886653-175320066 bp, - strand Genetic Position: Chr1, 81.11 cM
• Alliance: Rgs7^tm1.1Kama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184794
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 and C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 4. A loxP site and FRT-flanked neomycin selection cassette was inserted downstream of exon 4. Cre-mediated recombination removed exon 4 and the neomycin selection cassette. Western blot analysis confirmed the absence of protein expression in the retina. (J:184794)

Generation of the Rgs7^tm1.1Kama allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs7 Mutation: 25 strains or lines available

References

• Original: J:184794 Cao Y, et al., Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7905-10
• All: 12 reference(s)