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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fzd9tm1Uta
targeted mutation 1, Uta Francke
MGI:3526665
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fzd9tm1Uta/Fzd9tm1Uta involves: 129S6/SvEvTac * 129X1/SvJ MGI:3578414
hm2
Fzd9tm1Uta/Fzd9tm1Uta involves: 129X1/SvJ MGI:4946080
ht3
Fzd9tm1Uta/Fzd9+ involves: 129X1/SvJ MGI:4946081


Genotype
MGI:3578414
hm1
Allelic
Composition
Fzd9tm1Uta/Fzd9tm1Uta
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd9tm1Uta mutation (1 available); any Fzd9 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• exhibit moderately reduced lifespans

immune system
• exhibit accelerated atrophy with age
• reduction in CD43+B220+ pro/pre-B-cell populations
• decreased total B-cell number in the bone marrow despite relatively normal numbers of mature B cells in the periphery
• reduction in CD43+B220+ pro/pre-B-cell populations
• older homozygous null mice have a high frequency of peripheral blood leukocytosis
• older homozygous null mice exhibit eosinophilia
• older homozygous null mice exhibit mild neutrophilia
• older homozygous null mice exhibit monocytosis
• expansion of the red pulp with increased extramedullary hematopoiesis and deposition of increased amounts of hemosiderin
• spleens are approximately twice the normal size by 6 months of age
• although the white pulp is intact, there is some expansion of the marginal zones
• variably distorted nodal architecture
• an accumulation of plasma cells that filled and distended the medullary cords and were present in large patches in the paracortical zones
• lymph nodes are frequently enlarged, even at 3 months of age, with more than 50% of older homozygous null mice showing enlarged lymph nodes

hematopoietic system
• exhibit accelerated atrophy with age
• reduction in CD43+B220+ pro/pre-B-cell populations
• decreased total B-cell number in the bone marrow despite relatively normal numbers of mature B cells in the periphery
• reduction in CD43+B220+ pro/pre-B-cell populations
• older homozygous null mice have a high frequency of peripheral blood leukocytosis
• older homozygous null mice exhibit eosinophilia
• older homozygous null mice exhibit mild neutrophilia
• older homozygous null mice exhibit monocytosis
• expansion of the red pulp with increased extramedullary hematopoiesis and deposition of increased amounts of hemosiderin
• spleens are approximately twice the normal size by 6 months of age
• although the white pulp is intact, there is some expansion of the marginal zones

behavior/neurological
N
• do not exhibit any neurological, reflex or behavioral problems or hyperacusis

endocrine/exocrine glands
• exhibit accelerated atrophy with age

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Williams-Beuren Syndrome; WBS 194050 J:98133




Genotype
MGI:4946080
hm2
Allelic
Composition
Fzd9tm1Uta/Fzd9tm1Uta
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd9tm1Uta mutation (1 available); any Fzd9 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• reduction in vertebral bodies by 35% and 40% at 24 and 52 weeks of age, respectively
• reduction in cortical thickness of femurs
• 30% reduction is osteoblast number
• however, no differences in osteoclast number
• osteoblastogenesis defect
• isolated bone marrow cells grown in culture exhibit reduced mineralization after differentiation into osteoblasts but normal osteoclastogenesis
• calvaria-derived osteoblasts grown in culture for up to 20 days exhibit poor mineralization
• 45% reduction in bone formation rate
• calvaria-derived osteoblasts grown in culture in the presence of ascorbate and beta-glycerophosphate exhibit a decrease in proliferation at day 2 of differentiation
• vertebral bodies and femora exhibit decreased biomechanical competence

cellular
• osteoblastogenesis defect




Genotype
MGI:4946081
ht3
Allelic
Composition
Fzd9tm1Uta/Fzd9+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd9tm1Uta mutation (1 available); any Fzd9 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• reduction in cortical thickness of femurs
• decrease in bone rate formation
• vertebral bodies and femora exhibit decreased biomechanical competence

Mouse Models of Human Disease
OMIM ID Ref(s)
Williams-Beuren Syndrome; WBS 194050 J:169924





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory