Phenotypes associated with this allele

• Allele Symbol: Homer2^tm1Mhd
• Allele Name: targeted mutation 1, Marlin H Dehoff
• Allele ID: MGI:3526530
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Homer2^tm1Mhd/Homer2^tm1Mhd	B6.129-Homer2^tm1Mhd	MGI:3716979
hm2	Homer2^tm1Mhd/Homer2^tm1Mhd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3526582
cx3	Homer2^tm1Mhd/Homer2^tm1Mhd Homer3^tm1Mhd/Homer3^tm1Mhd	involves: 129S1/Sv * 129X1/SvJ	MGI:5461825

Genotype
MGI:3716979

hm1

• Allelic Composition: Homer2^tm1Mhd/Homer2^tm1Mhd
• Genetic Background: B6.129-Homer2^tm1Mhd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:96554 )

N

enhanced behavioral response to cocaine ( J:96554 )

• capacity of acute cocaine to elicit locomotor hyperactivity is enhanced in mutants compared to controls

abnormal cocaine consumption ( J:96554 )

• mutants acquire operant self-administration of cocaine more readily than controls

abnormal associative learning ( J:96554 )

• mutants exhibit cocaine-induced place conditioning compared to wild-type controls

• mice exhibit cocaine-induced place conditioning (increased time spent in environment containing stimulus/reward) at doses that do not elicit place conditioning in controls

• mutants acquire operant self-administration of cocaine more readily than controls

enhanced conditioned place preference behavior ( J:96554 )

• mice prefer to spend more time in chamber where cocaine is available compared to controls

nervous system

abnormal nervous system physiology ( J:96554 )

• mutants show lower (~50%) extracellular glutamate levels in the nucleus accumbens compared to wild-type mice; injection of cocaine into the nucleus accumbens causes elevation of extracellular glutamate levels in mutants but not wild-type controls

Genotype
MGI:3526582

hm2

• Allelic Composition: Homer2^tm1Mhd/Homer2^tm1Mhd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

endocrine/exocrine glands

abnormal pancreas physiology ( J:95213 )

• carbachol stimulated acinar cells showed a higher increase in intracellular calcium concentration due to increased calcium release from internal stores than controls

• two-fold increased frequency of intracellular calcium oscillations in acinar cells in response to stimulation with bombesin or CCK compared to controls

Genotype
MGI:5461825

cx3

• Allelic Composition: Homer2^tm1Mhd/Homer2^tm1Mhd; Homer3^tm1Mhd/Homer3^tm1Mhd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

behavior/neurological

abnormal nociception after inflammation ( J:191366 )

♂ • formalin-treated mice exhibit greater response to pain during the second phase, but not the first phase, compared with wild-type mice