Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Srctm1Mul mutation
(0 available);
any
Src mutation
(144 available)
Tg(MMTV-cre)7Mul mutation
(0 available)
Tg(MMTV-PyVT)#Mul mutation
(0 available)
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neoplasm
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N |
• mice exhibit the same incidence of lung metastases and average metastatic burden as in Tg(MMTV-PyVT)#Mul mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srctm1Mul mutation
(0 available);
any
Src mutation
(144 available)
Tg(MMTV-cre)7Mul mutation
(0 available)
Tg(MMTV-PyVT)#Mul mutation
(0 available)
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Analysis of tumorigenesis
neoplasm
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• with later onset than in Tg(MMTV-PyVT)#Mul mice
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endocrine/exocrine glands
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• with later onset than in Tg(MMTV-PyVT)#Mul mice
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integument
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• with later onset than in Tg(MMTV-PyVT)#Mul mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srctm1Mul mutation
(0 available);
any
Src mutation
(144 available)
Tg(MMTV-cre)7Mul mutation
(0 available)
Tg(MMTV-PyVT)#Mul mutation
(0 available)
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Analysis of tumorigenesis
neoplasm
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• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice
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integument
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• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice
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endocrine/exocrine glands
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• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srctm1Mul mutation
(0 available);
any
Src mutation
(144 available)
Tg(MMTV-PyVT)#Mul mutation
(0 available)
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cellular
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• of tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen
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• of tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen
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neoplasm
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• tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen exhibit impaired proliferation, increased apoptosis and restored cell-cell adhesion compared to in Tg(MMTV-PyVT)#Mul mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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neoplasm
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• mice develop mammary carcinomas with 100% penetrance
• primary tumors develop at varying ages, with the first masses seen between 90-120 days of age
• tumors comprise primarily of solid, glandular and acinar forms and often contain cystic areas
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• progression to pulmonary metastases is seen in more than 95% of mice more than 130 days of age
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immune system
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• B cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
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• splenocytes from mice with tumor loads show reduced proliferative responses in response to mitogens
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• enlarged spleen in mice with tumors, with mice with the highest tumor burdens having the largest spleens
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• percentage of tumor-infiltrating Treg cells is increased
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• percentage of macrophage-like populations and myeloid cells in the spleen increase with increasing tumor load, with a corresponding decrease in the percentage of T cells
• however, percentage of NKT cells in the spleen is similar to controls
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• total number of splenocytes increases progressively with increasing tumor burden
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• T cells from CD3/CD28-stimulated splenocytes from tumor-bearing mice produce lower levels of IFN-gamma
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• T cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
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• tumor-bearing mice show increased serum levels of pro-inflammatory cytokines MCP-1 and TNF-alpha
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• total number of lymph node cells in tumor-draining lymph nodes increases progressively until a total tumor burden between 8 and 12 cm3 is reached, after which a decrease in lymph node cell numbers is seen
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• increase in the percentages of B cells within the tumor-draining lymph nodes of mice with extensive tumor loads
• however, percentage of NKT cells in the tumor-draining lymph nodes is similar to controls
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homeostasis/metabolism
hematopoietic system
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• B cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
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• splenocytes from mice with tumor loads show reduced proliferative responses in response to mitogens
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• enlarged spleen in mice with tumors, with mice with the highest tumor burdens having the largest spleens
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• percentage of tumor-infiltrating Treg cells is increased
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• myeloid cells in the spleen are increased in tumor-bearing mice
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• percentage of macrophage-like populations and myeloid cells in the spleen increase with increasing tumor load, with a corresponding decrease in the percentage of T cells
• however, percentage of NKT cells in the spleen is similar to controls
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• total number of splenocytes increases progressively with increasing tumor burden
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• T cells from CD3/CD28-stimulated splenocytes from tumor-bearing mice produce lower levels of IFN-gamma
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• T cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
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cellular
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• B cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
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• T cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
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• splenocytes from mice with tumor loads show reduced proliferative responses in response to mitogens
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endocrine/exocrine glands
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• mice develop mammary carcinomas with 100% penetrance
• primary tumors develop at varying ages, with the first masses seen between 90-120 days of age
• tumors comprise primarily of solid, glandular and acinar forms and often contain cystic areas
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integument
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• mice develop mammary carcinomas with 100% penetrance
• primary tumors develop at varying ages, with the first masses seen between 90-120 days of age
• tumors comprise primarily of solid, glandular and acinar forms and often contain cystic areas
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growth/size/body
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• enlarged spleen in mice with tumors, with mice with the highest tumor burdens having the largest spleens
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Analysis Tools