Phenotypes associated with this allele

• Allele Symbol: Itgb4^tm2Fgg
• Allele Name: targeted mutation 2, Filippo G Giancotti
• Allele ID: MGI:3524974
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb4^tm2Fgg/Itgb4^tm2Fgg	involves: 129/Sv * C57BL/6	MGI:3525267

Genotype
MGI:3525267

hm1

• Allelic Composition: Itgb4^tm2Fgg/Itgb4^tm2Fgg
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased angiogenesis ( J:94627 )

• cardiovascular development is normal however vascular regrowth is reduced in the retina in response to hypoxia following loss of vessels during a hyperoxic exposure

• tumor angiogenesis is also reduced for multiple lines of injected tumor cells resulting in reduced tumor growth, however in an orthotopic model of mammary carcinogenesis tumor vascularization and growth were not different from wild-type

integument

integument phenotype ( J:94627 )

N • the skin is not fragile and no defects in epidermal adhesion to the basement membrane are seen