About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Txnrd2tm1Marc
targeted mutation 1, Marcus Conrad
MGI:3512408
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Myl2tm1(cre)Krc/Myl2+
Txnrd2tm1Marc/Txnrd2tm1.1Marc
involves: 129P2/OlaHsd * C57BL/6 MGI:3512422
cn2
Txnrd2tm1Marc/Txnrd2tm1Marc
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3778635


Genotype
MGI:3512422
cn1
Allelic
Composition
Myl2tm1(cre)Krc/Myl2+
Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (11 available)
Txnrd2tm1.1Marc mutation (0 available); any Txnrd2 mutation (9 available)
Txnrd2tm1Marc mutation (0 available); any Txnrd2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die within several hours after birth

cardiovascular system
• liver congestion
• myocardial cells are severely distorted with pycnotic nuclei, cytoplasmic vacuolization, reduced cross-striation, and swollen or destroyed mitochondrial cristae
• globular heart shape
• mutants show clinical features of congestive heart failure

homeostasis/metabolism

liver/biliary system
• liver congestion

muscle
• myocardial cells are severely distorted with pycnotic nuclei, cytoplasmic vacuolization, reduced cross-striation, and swollen or destroyed mitochondrial cristae




Genotype
MGI:3778635
cn2
Allelic
Composition
Txnrd2tm1Marc/Txnrd2tm1Marc
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Txnrd2tm1Marc mutation (0 available); any Txnrd2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal brain morphology

normal phenotype
• mice do not display any overt phenotype





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/01/2019
MGI 6.14
The Jackson Laboratory