Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation
(2 available);
any
Nrp1 mutation
(81 available)
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immune system
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• defective T-cell priming by antigen
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• impaired dendritic cell migration
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vision/eye
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• mice exhibit normal retinal stratification
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hematopoietic system
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• defective T-cell priming by antigen
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation
(2 available);
any
Nrp1 mutation
(81 available)
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mortality/aging
cardiovascular system
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• exhibited bilateral atrial enlargement, however no vascular branching defects were observed
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growth/size/body
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• 70% of P7 survivors are growth retarded
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nervous system
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• guidance of ophthalmic nerve axons and cutaneous sensory neurons was abnormal so that projections extended beyond their normal zones
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• callosal axons displayed varying degrees of defasciculation with agenesis of corpus callosum resulting in the formation of Probst bundles in extreme cases
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• entorhinohippocampal axons were no longer restricted in the stratum lacunosum-moleculare of the ipsilateral hippocampus with many fibers innervating ectopic layers
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• defasciculated and abnormally extended ophthalmic branch of the trigeminal nerve, however defects were less severe than in Nrp1tm2.1Ddg
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• E12.5 mutants have additional smaller fiber bundles that extend beyond their normal termination zones within the sensory end organs with projection defects persisting at E14.5 and E15.5
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• many cutaneous afferent axons entered the gray matter a E14.5 with some projections extending into the most ventral regions of the spinal cord
• at P2, some axons were outside their normal termination zones, along the midline and in the medial-ventral spinal cord
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• disorganized peripheral projections of spinal nerves in E11.5 mutants
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cellular
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• guidance of ophthalmic nerve axons and cutaneous sensory neurons was abnormal so that projections extended beyond their normal zones
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation
(2 available);
any
Nrp1 mutation
(81 available)
Nrp2tm1Ddg mutation
(0 available);
any
Nrp2 mutation
(88 available)
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cardiovascular system
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• persistent truncus arteriosis is seen; however, somitic vasculature is normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation
(2 available);
any
Nrp1 mutation
(81 available)
Tg(Thy1-YFP)16Jrs mutation
(1 available)
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nervous system
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• basal dendrites of layer 5 cortical neurons within the neocortex were markedly diminished in length and complexity
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation
(2 available);
any
Nrp1 mutation
(81 available)
Nrp2tm1Ddg mutation
(0 available);
any
Nrp2 mutation
(88 available)
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cardiovascular system
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• 66% of mutants exhibited truncus arteriosis compared to none in either single homozygous mutants
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• exhibited bilateral atrial enlargement
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