Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga7tm1Burk mutation
(1 available);
any
Itga7 mutation
(35 available)
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mortality/aging
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• 5% of mutants do not survive past 4 weeks of age
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muscle
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• mutants exhibit evidence of muscle necrosis at 4.5 months of age
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• mutants exhibit centrally placed nuclei in muscle at 4.5 months of age
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• mutants exhibit an increase in interstitial connective tissue between myofibers of the diaphragm
• mutants exhibit an increase in collagen deposition in the diaphragm at 6 months of age
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• diaphragms and quadriceps muscles exhibit greater numbers of larger myofibers and fewer small fibers
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• diaphragms exhibit a 30% reduction in specific muscle force values compared with wild-type
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• mutants exhibit mild myopathy at 4.5 months of age, evidenced by necrosis and centrally placed nuclei in muscle
• however, pathological symptoms remain absent
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skeleton
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• mild kyphosis at 4.5 months of age
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cellular
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• mutants exhibit evidence of muscle necrosis at 4.5 months of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga7tm1Burk mutation
(1 available);
any
Itga7 mutation
(35 available)
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mortality/aging
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• approximately 68% of homozygotes die before birth; surviving homozygotes are viable and fertile
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cardiovascular system
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• reduced cerebral vascularization with hemorrhaging during embryonic development
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• histology of cerebral arteries from E13.5 homozygotes shows disrupted smooth muscle actin and hypoplasia
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• histology of cerebral arteries of 5 week old homozygotes shows smooth muscle cell hyperplasia
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• E13.5 cerebral vascular smooth muscle cells appear larger than normal
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• varying degrees of embryonic hemorrhaging, often associated with decreased cerebral vascularization
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• cerebrovascular hemorrhage and other vascular trauma found in E10.5-E14.5 embryos
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muscle
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• histology of cerebral arteries from E13.5 homozygotes shows disrupted smooth muscle actin and hypoplasia
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• histology of cerebral arteries of 5 week old homozygotes shows smooth muscle cell hyperplasia
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• E13.5 cerebral vascular smooth muscle cells appear larger than normal
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• at 5 weeks of age, centrally located nuclei are found in approximately 17% of muscle fibers
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nervous system
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• cerebrovascular hemorrhage and other vascular trauma found in E10.5-E14.5 embryos
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mortality/aging
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• 10% of mutants do not survive past 4 weeks of age and by 8 months of age, viability it reduced to 50%
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growth/size/body
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• reduced body weight compared to wild-type and Sspn single homozygotes
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muscle
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• quadriceps muscles show severely diminished levels of laminin and sarcolemma damage
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• quadriceps muscle weights less than in either single homozygote
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• quadriceps muscles at 4.5 months of age exhibit sarcolemma damage as indicated by Evan's blue dye accumulation
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• mutants exhibit myopathy at 4.5 months of age, with centrally placed nuclei in skeletal muscles indicating muscle regeneration
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• mutants exhibit a greater increase in interstitial connective tissue between myofibers of the diaphragm compared to Itga7 single homozygotes
• mutants exhibit an increase in collagen deposition in the diaphragm and widespread fibrosis and adiposity at 4.5 months of age
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• diaphragms and quadriceps muscles exhibit greater numbers of small myofibers (more than 2-fold increase) and fewer larger fibers
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• reduced wet muscle mass compared to wild-type and Sspn single homozygotes
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• widespread fibrosis and adiposity in the diaphragm at 4.5 months of age and by 9 months of age, diaphragms show significant fibrotic collagen deposition and fat replacement
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• diaphragms exhibit a 51% reduction in specific muscle force values compared with wild-type
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• increase in myofiber regeneration at 4.5 months of age, with a 16-fold increase in regeneration in the diaphragm
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• mutants exhibit myopathy at 4.5 months of age
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homeostasis/metabolism
skeleton
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• severe kyphosis at 4.5 months of age as evidenced by the steep slope of the spine behind the shoulder blades, which is exacerbated at 6 months of age
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limbs/digits/tail
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• quadriceps muscles show severely diminished levels of laminin and sarcolemma damage
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• quadriceps muscle weights less than in either single homozygote
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