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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itga7tm1Burk
targeted mutation 1, Dean J Burkin
MGI:3512077
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itga7tm1Burk/Itga7tm1Burk involves: 129S1/Sv * 129X1/SvJ MGI:5440957
hm2
Itga7tm1Burk/Itga7tm1Burk involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3588505
cx3
Itga7tm1Burk/Itga7tm1Burk
Sspntm1Kcam/Sspntm1Kcam
involves: 129S1/Sv * 129X1/SvJ MGI:5440955


Genotype
MGI:5440957
hm1
Allelic
Composition
Itga7tm1Burk/Itga7tm1Burk
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga7tm1Burk mutation (1 available); any Itga7 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 5% of mutants do not survive past 4 weeks of age (J:187752)
• 5% of mutants do not survive past 4 weeks of age (J:187752)

muscle
• mutants exhibit centrally placed nuclei in muscle at 4.5 months of age (J:187752)
• mutants exhibit centrally placed nuclei in muscle at 4.5 months of age (J:187752)
• mutants exhibit an increase in interstitial connective tissue between myofibers of the diaphragm (J:187752)
• mutants exhibit an increase in collagen deposition in the diaphragm at 6 months of age (J:187752)
• mutants exhibit an increase in interstitial connective tissue between myofibers of the diaphragm (J:187752)
• mutants exhibit an increase in collagen deposition in the diaphragm at 6 months of age (J:187752)
• diaphragms and quadriceps muscles exhibit greater numbers of larger myofibers and fewer small fibers (J:187752)
• diaphragms and quadriceps muscles exhibit greater numbers of larger myofibers and fewer small fibers (J:187752)
• mutants exhibit evidence of muscle necrosis at 4.5 months of age (J:187752)
• mutants exhibit evidence of muscle necrosis at 4.5 months of age (J:187752)
• diaphragms exhibit a 30% reduction in specific muscle force values compared with wild-type (J:187752)
• diaphragms exhibit a 30% reduction in specific muscle force values compared with wild-type (J:187752)
• mutants exhibit mild myopathy at 4.5 months of age, evidenced by necrosis and centrally placed nuclei in muscle (J:187752)
• however, pathological symptoms remain absent (J:187752)
• mutants exhibit mild myopathy at 4.5 months of age, evidenced by necrosis and centrally placed nuclei in muscle (J:187752)
• however, pathological symptoms remain absent (J:187752)

skeleton
• mild kyphosis at 4.5 months of age (J:187752)
• mild kyphosis at 4.5 months of age (J:187752)




Genotype
MGI:3588505
hm2
Allelic
Composition
Itga7tm1Burk/Itga7tm1Burk
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga7tm1Burk mutation (1 available); any Itga7 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 68% of homozygotes die before birth; surviving homozygotes are viable and fertile (J:100236)
• approximately 68% of homozygotes die before birth; surviving homozygotes are viable and fertile (J:100236)

cardiovascular system
• reduced cerebral vascularization with hemorrhaging during embryonic development (J:100236)
• reduced cerebral vascularization with hemorrhaging during embryonic development (J:100236)
• histology of cerebral arteries from E13.5 homozygotes shows disrupted smooth muscle actin and hypoplasia (J:100236)
• histology of cerebral arteries from E13.5 homozygotes shows disrupted smooth muscle actin and hypoplasia (J:100236)
• histology of cerebral arteries of 5 week old homozygotes shows smooth muscle cell hyperplasia (J:100236)
• histology of cerebral arteries of 5 week old homozygotes shows smooth muscle cell hyperplasia (J:100236)
• E13.5 cerebral vascular smooth muscle cells appear larger than normal (J:100236)
• E13.5 cerebral vascular smooth muscle cells appear larger than normal (J:100236)
• varying degrees of embryonic hemorrhaging, often associated with decreased cerebral vascularization (J:100236)
• varying degrees of embryonic hemorrhaging, often associated with decreased cerebral vascularization (J:100236)
• cerebrovascular hemorrhage and other vascular trauma found in E10.5-E14.5 embryos (J:100236)
• cerebrovascular hemorrhage and other vascular trauma found in E10.5-E14.5 embryos (J:100236)

muscle
• histology of cerebral arteries from E13.5 homozygotes shows disrupted smooth muscle actin and hypoplasia (J:100236)
• histology of cerebral arteries from E13.5 homozygotes shows disrupted smooth muscle actin and hypoplasia (J:100236)
• histology of cerebral arteries of 5 week old homozygotes shows smooth muscle cell hyperplasia (J:100236)
• histology of cerebral arteries of 5 week old homozygotes shows smooth muscle cell hyperplasia (J:100236)
• E13.5 cerebral vascular smooth muscle cells appear larger than normal (J:100236)
• E13.5 cerebral vascular smooth muscle cells appear larger than normal (J:100236)
• at 5 weeks of age, centrally located nuclei are found in approximately 17% of muscle fibers (J:100236)
• at 5 weeks of age, centrally located nuclei are found in approximately 17% of muscle fibers (J:100236)

nervous system
• cerebrovascular hemorrhage and other vascular trauma found in E10.5-E14.5 embryos (J:100236)
• cerebrovascular hemorrhage and other vascular trauma found in E10.5-E14.5 embryos (J:100236)




Genotype
MGI:5440955
cx3
Allelic
Composition
Itga7tm1Burk/Itga7tm1Burk
Sspntm1Kcam/Sspntm1Kcam
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga7tm1Burk mutation (1 available); any Itga7 mutation (2 available)
Sspntm1Kcam mutation (2 available); any Sspn mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 10% of mutants do not survive past 4 weeks of age and by 8 months of age, viability it reduced to 50% (J:187752)
• 10% of mutants do not survive past 4 weeks of age and by 8 months of age, viability it reduced to 50% (J:187752)

growth/size/body
• reduced body weight compared to wild-type and Sspn single homozygotes (J:187752)
• reduced body weight compared to wild-type and Sspn single homozygotes (J:187752)

muscle
• quadriceps muscles at 4.5 months of age exhibit sarcolemma damage as indicated by Evan's blue dye accumulation (J:187752)
• quadriceps muscles at 4.5 months of age exhibit sarcolemma damage as indicated by Evan's blue dye accumulation (J:187752)
• mutants exhibit myopathy at 4.5 months of age, with centrally placed nuclei in skeletal muscles indicating muscle regeneration (J:187752)
• mutants exhibit myopathy at 4.5 months of age, with centrally placed nuclei in skeletal muscles indicating muscle regeneration (J:187752)
• mutants exhibit a greater increase in interstitial connective tissue between myofibers of the diaphragm compared to Itga7 single homozygotes (J:187752)
• mutants exhibit an increase in collagen deposition in the diaphragm and widespread fibrosis and adiposity at 4.5 months of age (J:187752)
• mutants exhibit a greater increase in interstitial connective tissue between myofibers of the diaphragm compared to Itga7 single homozygotes (J:187752)
• mutants exhibit an increase in collagen deposition in the diaphragm and widespread fibrosis and adiposity at 4.5 months of age (J:187752)
• quadriceps muscles show severely diminished levels of laminin and sarcolemma damage (J:187752)
• quadriceps muscles show severely diminished levels of laminin and sarcolemma damage (J:187752)
• quadriceps muscle weights less than in either single homozygote (J:187752)
• quadriceps muscle weights less than in either single homozygote (J:187752)
• diaphragms and quadriceps muscles exhibit greater numbers of small myofibers (more than 2-fold increase) and fewer larger fibers (J:187752)
• diaphragms and quadriceps muscles exhibit greater numbers of small myofibers (more than 2-fold increase) and fewer larger fibers (J:187752)
• reduced wet muscle mass compared to wild-type and Sspn single homozygotes (J:187752)
• reduced wet muscle mass compared to wild-type and Sspn single homozygotes (J:187752)
• widespread fibrosis and adiposity in the diaphragm at 4.5 months of age and by 9 months of age, diaphragms show significant fibrotic collagen deposition and fat replacement (J:187752)
• widespread fibrosis and adiposity in the diaphragm at 4.5 months of age and by 9 months of age, diaphragms show significant fibrotic collagen deposition and fat replacement (J:187752)
• diaphragms exhibit a 51% reduction in specific muscle force values compared with wild-type (J:187752)
• diaphragms exhibit a 51% reduction in specific muscle force values compared with wild-type (J:187752)
• increase in myofiber regeneration at 4.5 months of age, with a 16-fold increase in regeneration in the diaphragm (J:187752)
• increase in myofiber regeneration at 4.5 months of age, with a 16-fold increase in regeneration in the diaphragm (J:187752)
• mutants exhibit myopathy at 4.5 months of age (J:187752)
• mutants exhibit myopathy at 4.5 months of age (J:187752)

homeostasis/metabolism
• diaphragms exhibit increased susceptibility to eccentric contraction-induced damage as measured by the percent drop in force (J:187752)
• diaphragms exhibit increased susceptibility to eccentric contraction-induced damage as measured by the percent drop in force (J:187752)

skeleton
• severe kyphosis at 4.5 months of age as evidenced by the steep slope of the spine behind the shoulder blades, which is exacerbated at 6 months of age (J:187752)
• severe kyphosis at 4.5 months of age as evidenced by the steep slope of the spine behind the shoulder blades, which is exacerbated at 6 months of age (J:187752)

Mouse Models of Human Disease
OMIM ID Ref(s)
Muscular Dystrophy, Duchenne Type; DMD 310200 J:187752





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory