All Phenotypes Lepr<tm1.2Chua> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lepr^tm1.2Chua/Lepr^tm1.2Chua	involves: 129 * C57BL/6	MGI:3511748
hm2	Lepr^tm1.2Chua/Lepr^tm1.2Chua	involves: 129 * C57BL/6 * CBA	MGI:5142233
hm3	Lepr^tm1.2Chua/Lepr^tm1.2Chua	involves: 129 * C57BL/6J * FVB/N	MGI:3655811
cn4	Lepr^tm1.1Chua/Lepr^tm1.2Chua Nos1^tm1(cre)Mgmj/Nos1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5319227
cx5	Lepr^tm1.2Chua/Lepr^tm1.2Chua Nos1^tm1(cre)Mgmj/Nos1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5319228

Allelic Composition	Lepr^tm1.2Chua/Lepr^tm1.2Chua
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.2Chua mutation (0 available); any Lepr mutation (121 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Obesity in Lepr^tm1.2Chua/Lepr^tm1.2Chua mice

behavior/neurological

polyphagia ( J:94019 )

• males hyperphagic, consume 34.8% more food in a given period

growth/size/body

obese ( J:94019 )

increased susceptibility to weight gain ( J:94019 )

• males are 58.6% heavier than normal and females are 140.1% heavier

homeostasis/metabolism

impaired adaptive thermogenesis ( J:94019 )

• males are cold intolerant

abnormal glucose homeostasis ( J:94019 )

hyperglycemia ( J:94019 )

• males were severely hyperglycemic

increased circulating insulin level ( J:94019 )

• insulin concentration about 2.6X normal

reproductive system

infertility ( J:94019 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:94019

Allelic Composition	Lepr^tm1.2Chua/Lepr^tm1.2Chua
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.2Chua mutation (0 available); any Lepr mutation (121 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:174691 )

• animals display massive increase in body weight; weight increase is similar to that observed with conditional Lepr deletion in Slc32a1 (GABAergic) neurons

nervous system

abnormal inhibitory postsynaptic currents ( J:174691 )

• a large increase in amplitude and frequency of spontaneous IPSCs is observed in Pomc1 neurons in slice preparations from mice with global deletion of Lepr

Allelic Composition	Lepr^tm1.2Chua/Lepr^tm1.2Chua
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.2Chua mutation (0 available); any Lepr mutation (121 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:106354 )

• homozygotes are markedly obese; body weight and phenotype is identical to Lepr^db mice on similar genetic background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:106354

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:183754 )

• males have higher body weight relative to controls from 4-12 weeks similar to males with whole-body deletion of Lepr (Lepr^tm1.2Chua/ Lepr^tm1.2Chua; Nos1^tm1(cre)Mgmj/ Nos⁺ males)

• females display weight increase, but it is less severe than in females with whole-body deletion of Lepr

homeostasis/metabolism

increased circulating glucose level ( J:183754 )

• higher than controls from weaning age on in males and females

increased circulating corticosterone level ( J:183754 )

• circulating corticosterone levels in males are similar to controls

increased circulating insulin level ( J:183754 )

increased circulating leptin level ( J:183754 )

• starting at weaning age (8 weeks), much higher than controls at 8 weeks in males and females

decreased circulating thyroxine level ( J:183754 )

• levels of T4 are lower in males compared to controls; these levels are higher than in males with whole-body deletion of Lepr

decreased oxygen consumption ( J:183754 )

• males show decreased maximal oxygen consumption relative to controls at 12-14 weeks; oxygen consumption is similar to complete Lepr knockout males

adipose tissue

increased total body fat amount ( J:183754 )

• males have higher amount of adipose tissue similar to males with whole-body deletion of Lepr

behavior/neurological

behavior/neurological phenotype ( J:183754 )

N	• circulating corticosterone levels are similar to controls

increased food intake ( J:183754 )

• from 4-12 weeks, males show increased food intake relative to controls similar to males with whole-body deletion of Lepr

• females display increased food consumption, but it is less severe than in females with whole-body deletion of Lepr

decreased locomotor activity ( J:183754 )

• at 12-14 weeks, males show decreased ambulatory activity in both dark and light cycles in 24-hour period

• females show decreased ambulatory activity during the light cycle

reproductive system

reproductive system phenotype ( J:183754 )

N	• timing of litter delivery is similar to controls (24 days vs. 23 days in controls) and litter sizes are similar to controls

delayed estrous cycle ( J:183754 )

• onset of vaginal estrous is delayed relative to controls in singly housed females

Allelic Composition	Lepr^tm1.2Chua/Lepr^tm1.2Chua Nos1^tm1(cre)Mgmj/Nos1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.2Chua mutation (0 available); any Lepr mutation (121 available)
Nos1^tm1(cre)Mgmj mutation (1 available); any Nos1 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:183754 )

behavior/neurological

increased food intake ( J:183754 )

• males show increased food intake relative to controls; females display similar trend

decreased locomotor activity ( J:183754 )

• at 12-14 weeks, males show decreased ambulatory activity in both dark and light cycles in 24-hour period

• females show decreased ambulatory activity during both light and dark cycles; this is more significant than in females with conditional deletion of Lepr

growth/size/body

increased body weight ( J:183754 )

• males have higher body weight relative to controls at 12-14 weeks; females display similar trend

homeostasis/metabolism

increased circulating glucose level ( J:183754 )

• higher than controls from weaning age on in males and females

increased circulating corticosterone level ( J:183754 )

• levels are higher in males than in controls

increased circulating insulin level ( J:183754 )

• starting at weaning age (8 weeks), much higher than controls at 8 weeks in both males and females

increased circulating leptin level ( J:183754 )

• starting at weaning age (8 weeks), much higher than controls in both males and females

decreased circulating thyroxine level ( J:183754 )

• levels of T4 are lower in males compared to controls; levels are higher than in conditional Lepr knockout males

decreased oxygen consumption ( J:183754 )

• males show decreased maximal oxygen consumption relative to controls at 12-14 weeks

• females display a similarly decreased VO2

reproductive system

reduced female fertility ( J:183754 )

• majority of females fail to deliver litters within 6 weeks of mating

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