Mouse Genome Informatics
hm1
    Sncatm1Sud/Sncatm1Sud
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• no signs of Parkinsonism in mice up to ages beyond 1 year
• resistant to the lethal effects of MPTP and less paralysis at the highest doses
• at lower MPTP doses, dopamine losses about half what is seen in controls
• effects of metamphetamine were opposite, 47% decrease in dopamine as compared to a 25% decrease in controls


Mouse Genome Informatics
cx2
    Dnajc5tm1Sud/Dnajc5tm1Sud
Sncatm1Sud/Sncatm1Sud
Sncbtm1.1Sud/Sncbtm1.1Sud

involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die suddenly within a few days after weaning (average lifespan ~23.8 days); even if mutants are left with the mother, survival is <30 days

growth/size/body
• at P8, triple mutants weigh less than their littermates and at P20 are ~50% of wild-type littermates

nervous system
• degenerating neurons are found in brain and spinal cord of mutants
• mice show accelerated degeneration relative to Dnajc5-null animals at 10 days of age


Mouse Genome Informatics
cx3
    Sncatm1Sud/Sncatm1Sud
Sncbtm1.1Sud/Sncbtm1.1Sud

involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• dopamine levels decreased by 18% in the striatum but metabolic levels are normal
• dopamine levels decreased by 18% in the striatum but metabolic levels are normal

homeostasis/metabolism
• dopamine levels decreased by 18% in the striatum but metabolic levels are normal


Mouse Genome Informatics
cx4
    Dnajc5tm1Sud/Dnajc5tm1Sud
Sncatm1Sud/Sncatm1Sud

involves: 129P2/OlaHsd * 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• double mutants display intermediate lifespan with average length between that of Snca,Dnajc5 double-null mice and Dnajc5-null mice