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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sncatm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:3487373
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sncatm1Sud/Sncatm1Sud involves: 129P2/OlaHsd * C57BL/6 MGI:3510542
cx2
Dnajc5tm1Sud/Dnajc5tm1Sud
Sncatm1Sud/Sncatm1Sud
Sncbtm1.1Sud/Sncbtm1.1Sud
involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:3768080
cx3
Sncatm1Sud/Sncatm1Sud
Sncbtm1.1Sud/Sncbtm1.1Sud
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3511218
cx4
Dnajc5tm1Sud/Dnajc5tm1Sud
Sncatm1Sud/Sncatm1Sud
involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3768084


Genotype
MGI:3510542
hm1
Allelic
Composition
Sncatm1Sud/Sncatm1Sud
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sncatm1Sud mutation (1 available); any Snca mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• no signs of Parkinsonism in mice up to ages beyond 1 year
• resistant to the lethal effects of MPTP and less paralysis at the highest doses
• at lower MPTP doses, dopamine losses about half what is seen in controls
• effects of metamphetamine were opposite, 47% decrease in dopamine as compared to a 25% decrease in controls




Genotype
MGI:3768080
cx2
Allelic
Composition
Dnajc5tm1Sud/Dnajc5tm1Sud
Sncatm1Sud/Sncatm1Sud
Sncbtm1.1Sud/Sncbtm1.1Sud
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc5tm1Sud mutation (1 available); any Dnajc5 mutation (19 available)
Sncatm1Sud mutation (1 available); any Snca mutation (17 available)
Sncbtm1.1Sud mutation (1 available); any Sncb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die suddenly within a few days after weaning (average lifespan ~23.8 days); even if mutants are left with the mother, survival is <30 days

growth/size/body
• at P8, triple mutants weigh less than their littermates and at P20 are ~50% of wild-type littermates

nervous system
• degenerating neurons are found in brain and spinal cord of mutants
• mice show accelerated degeneration relative to Dnajc5-null animals at 10 days of age




Genotype
MGI:3511218
cx3
Allelic
Composition
Sncatm1Sud/Sncatm1Sud
Sncbtm1.1Sud/Sncbtm1.1Sud
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sncatm1Sud mutation (1 available); any Snca mutation (17 available)
Sncbtm1.1Sud mutation (1 available); any Sncb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• dopamine levels decreased by 18% in the striatum but metabolic levels are normal
• dopamine levels decreased by 18% in the striatum but metabolic levels are normal

homeostasis/metabolism
• dopamine levels decreased by 18% in the striatum but metabolic levels are normal




Genotype
MGI:3768084
cx4
Allelic
Composition
Dnajc5tm1Sud/Dnajc5tm1Sud
Sncatm1Sud/Sncatm1Sud
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc5tm1Sud mutation (1 available); any Dnajc5 mutation (19 available)
Sncatm1Sud mutation (1 available); any Snca mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double mutants display intermediate lifespan with average length between that of Snca,Dnajc5 double-null mice and Dnajc5-null mice





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory