Mouse Genome Informatics
cx1
    Apoetm1Unc/Apoetm1Unc
Tg(GFAP-APOE_i3)37Hol/0

B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i3)37Hol
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• mice exhibit increased protected risk assessment behaviors in an elevated plus maze compared to wild-type mice
• mice consume food slower in a new environment than Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc and wild-type mice
• mice require more time to habituate to a novel environment compared to wild-type mice
• mice are less reluctant than wild-type mice to move into an open area
• at 14 to 17 months of age, mice perform better than Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc and wild-type mice in a rotating holeboard test
• compared to wild-type mice
• mice spend less time than wild-type mice in the center of an open field
• mice exhibit increased numbers of fine movement (not related to ambulation) compared to wild-type mice


Mouse Genome Informatics
cx2
    Apoetm1Unc/Apoetm1Unc
Tg(GFAP-APOE_i3)37Hol/0

B6.Cg-Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• in vitro, neuron outgrowth is faster than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• in vitro, neurite length is longer than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• however, neurite outgrowth rate is equivalent to in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons when neurons are treated with RAP or anti-LRP IgG
• the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoetm1Unc homozygotes

cellular
• in vitro, neuron outgrowth is faster than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• in vitro, neurite length is longer than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• however, neurite outgrowth rate is equivalent to in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons when neurons are treated with RAP or anti-LRP IgG


Mouse Genome Informatics
cx3
    Apoetm1Unc/Apoetm1Unc
Tg(APPV717F)109Ili/0
Tg(GFAP-APOE_i3)37Hol/0

involves: 129P2/OlaHsd * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• by 15 to 18 months, 31% of mice exhibit plaques in the hippocampus (J:127846)
• the amount of amyloid deposited is less than in Tg(APPV717F)109Ili Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc and much less than in Tg(APPV717F)109Ili Apoetm1Unc/Apoetm1Unc mice (J:127846)
• plaques are observed in the the outer molecular layer of the dentate gyrus and the stratum oriens and radiatum of the hippocampus (J:127846)
• mice exhibit fibrillar plaques in the outer molecular layer of the dentate gurys (J:127846)
• 20% of mice exposed to traumatic brain injury (TBI) at 9 to 10 months of age exhibit amyloid plaques by 12 to 13 months of age while mice not exposed to TBI do not exhibit plaques until 15 months of age (J:133058)
• mice exhibit decreased plaque formation and severity following TBI compared to in similarly treated Tg(APPV717F)109Ili Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc mice (J:133058)

homeostasis/metabolism
• by 15 to 18 months, 31% of mice exhibit plaques in the hippocampus (J:127846)
• the amount of amyloid deposited is less than in Tg(APPV717F)109Ili Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc and much less than in Tg(APPV717F)109Ili Apoetm1Unc/Apoetm1Unc mice (J:127846)
• plaques are observed in the the outer molecular layer of the dentate gyrus and the stratum oriens and radiatum of the hippocampus (J:127846)
• mice exhibit fibrillar plaques in the outer molecular layer of the dentate gurys (J:127846)
• 20% of mice exposed to traumatic brain injury (TBI) at 9 to 10 months of age exhibit amyloid plaques by 12 to 13 months of age while mice not exposed to TBI do not exhibit plaques until 15 months of age (J:133058)
• mice exhibit decreased plaque formation and severity following TBI compared to in similarly treated Tg(APPV717F)109Ili Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc mice (J:133058)


Mouse Genome Informatics
cx4
    Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Tg(GFAP-APOE_i3)37Hol/0

involves: 129P2/OlaHsd * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice

nervous system
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice
• mice exhibit less severe microgliosis following medial cerebral artery occlusion compared to Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice