Phenotypes associated with this allele
behavior/neurological
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• mice consume food slower in a new environment than Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc and wild-type mice
• mice require more time to habituate to a novel environment compared to wild-type mice
• mice are less reluctant than wild-type mice to move into an open area
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• at 14 to 17 months of age, mice perform better than Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc and wild-type mice in a rotating holeboard test
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• mice exhibit increased protected risk assessment behaviors in an elevated plus maze compared to wild-type mice
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• compared to wild-type mice
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• mice exhibit increased numbers of fine movement (not related to ambulation) compared to wild-type mice
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• mice spend less time than wild-type mice in the center of an open field
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nervous system
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• in vitro, neuron outgrowth is faster than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• in vitro, neurite length is longer than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• however, neurite outgrowth rate is equivalent to in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons when neurons are treated with RAP or anti-LRP IgG
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• the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoetm1Unc homozygotes
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cellular
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• in vitro, neuron outgrowth is faster than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• in vitro, neurite length is longer than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• however, neurite outgrowth rate is equivalent to in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons when neurons are treated with RAP or anti-LRP IgG
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation
(33 available);
any
Apoe mutation
(145 available)
Tg(APPV717F)109Ili mutation
(0 available)
Tg(GFAP-APOE_i3)37Hol mutation
(1 available)
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nervous system
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• by 15 to 18 months, 31% of mice exhibit plaques in the hippocampus
(J:127846)
• the amount of amyloid deposited is less than in Tg(APPV717F)109Ili Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc and much less than in Tg(APPV717F)109Ili Apoetm1Unc/Apoetm1Unc mice
(J:127846)
• plaques are observed in the the outer molecular layer of the dentate gyrus and the stratum oriens and radiatum of the hippocampus
(J:127846)
• mice exhibit fibrillar plaques in the outer molecular layer of the dentate gurys
(J:127846)
• 20% of mice exposed to traumatic brain injury (TBI) at 9 to 10 months of age exhibit amyloid plaques by 12 to 13 months of age while mice not exposed to TBI do not exhibit plaques until 15 months of age
(J:133058)
• mice exhibit decreased plaque formation and severity following TBI compared to in similarly treated Tg(APPV717F)109Ili Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc mice
(J:133058)
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation
(33 available);
any
Apoe mutation
(145 available)
Tg(Eno2-APP*751)10Cord mutation
(0 available)
Tg(GFAP-APOE_i3)37Hol mutation
(1 available)
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homeostasis/metabolism
nervous system
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• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice
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• mice exhibit less severe microgliosis following medial cerebral artery occlusion compared to Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice
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Analysis Tools