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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(IRS1)1Mhep
transgene insertion 1, Rolf Carlson
MGI:3056765
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(IRS1)1Mhep/0
Tg(SERPINA1-HBVX)1655Jtsb/0 		involves: C3H * C57BL/6 * FVB * ICR MGI:5706939
tg2
 		Tg(IRS1)1Mhep/0 FVB-Tg(IRS1)1Mhep MGI:3835313


Genotype
MGI:5706939
cx1
Allelic
Composition		 Tg(IRS1)1Mhep/0
Tg(SERPINA1-HBVX)1655Jtsb/0
Genetic
Background		 involves: C3H * C57BL/6 * FVB * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IRS1)1Mhep mutation (1 available)
Tg(SERPINA1-HBVX)1655Jtsb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
hepatic steatosis ( J:227278 )
• 9 month old males exhibit substantial dysplastic, steatosis and lobular architectural changes in the liver
• 9 month old females exhibit only mild steatosis
increased hepatocellular carcinoma incidence ( J:227278 )
• males, but not females, develop hepatocellular carcinoma starting at 15-18 months of age
• tumors vary in appearance, size and location, from multiple tiny nodules covering the entire liver to a single large mass

neoplasm
increased hepatocellular carcinoma incidence ( J:227278 )
• males, but not females, develop hepatocellular carcinoma starting at 15-18 months of age
• tumors vary in appearance, size and location, from multiple tiny nodules covering the entire liver to a single large mass

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
 J:227278




Genotype
MGI:3835313
tg2
Allelic
Composition		 Tg(IRS1)1Mhep/0
Genetic
Background		 FVB-Tg(IRS1)1Mhep
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IRS1)1Mhep mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte proliferation ( J:92999 )
• at 3 months of age
increased liver weight ( J:92999 )
• at 3 months of age, liver weight to body weight is increased compared to in wild-type mice

cellular
increased hepatocyte proliferation ( J:92999 )
• at 3 months of age

growth/size/body
increased liver weight ( J:92999 )
• at 3 months of age, liver weight to body weight is increased compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory