Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Tg(HLA-A2.1)1Enge mutation
(7 available);
any
Mcph1 mutation
(58 available)
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immune system
N |
• proportions of splenic B cells, CD4, and CD8 T cells are comparable to controls; no differences in CD4+CD25+ T cell numbers or expression levels of endogenous murine MHC class I molecules are found
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• homozygous and hemizygous mice develop type I diabetes at a significantly accelerated rate compared to NOD controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Tg(HLA-A2.1)1Enge mutation
(7 available);
any
Mcph1 mutation
(58 available)
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immune system
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• transgenic animals are more tolerant to HLA-A2.1-expressing murine cells than control mice primed once with influenza virus; numbers of cytotoxic T lymphocyte precursors are 100-fold higher in primed C57BL/6 controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Tg(HLA-A2.1)1Enge mutation
(7 available);
any
Mcph1 mutation
(58 available)
|
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immune system
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• homozygous and hemizygous mice develop type I diabetes at a significantly accelerated rate compared to NOD controls
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immune system
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• these mice do not develop diabetes and they provide a host in cell transfer studies for assessing HLA-A2.1 selected T cell pathogenicity
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immune system
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• mice develop diabetes at a rate similar to NOD control females, whereas transgenic animals not expressing Tg(HLA-A2.1)1Enge are normally diabetes-resistant
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hematopoietic system
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• more than 95% of splenocytes express high levels of human HLA-A2.1 protein on their cell surface
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immune system
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• more than 95% of splenocytes express high levels of human HLA-A2.1 protein on their cell surface
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homeostasis/metabolism
immune system
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• when islet and HLA-A2 negative human peripheral blood mononuclear cells are transplanted into streptozotocin-treated Rag1tm1Mom Prf1tm1Sdz homozygotes engrafted islet cells are destroyed
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