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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sil1wz
woozy
MGI:3055918
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sil1wz/Sil1wz CXB5/ByJ-Sil1wz MGI:3640086
ht2
Sil1Gt(RST462)Byg/Sil1wz involves: 129P2/OlaHsd * C57BL/6J * CXB5/ByJ MGI:3640087


Genotype
MGI:3640086
hm1
Allelic
Composition
Sil1wz/Sil1wz
Genetic
Background
CXB5/ByJ-Sil1wz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sil1wz mutation (1 available); any Sil1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

behavior/neurological
• develop adult-onset ataxia

nervous system
• degenerating Purkinje cells have condensed nuclear chromatin, multilamellar membranous structures with characteristics of autophagosomes or autophagic vacuoles, and intracellular protein accumulations in the ER and nucleus
• most Purkinje cells in cerebellar lobules degenerate by 4 months of age, however cells in lobule X and caudal lobule IX are present in mice at 1 year of age
• Purkinje cells exhibit upregulation of the unfolded protein response, suggestive of ER stress




Genotype
MGI:3640087
ht2
Allelic
Composition
Sil1Gt(RST462)Byg/Sil1wz
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CXB5/ByJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sil1Gt(RST462)Byg mutation (0 available); any Sil1 mutation (23 available)
Sil1wz mutation (1 available); any Sil1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• develop adult-onset ataxia

nervous system
• exhibit the same phenotype and pathology as homozygous Sil1wz mice





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory