Phenotypes associated with this allele

• Allele Symbol: Map3k8^tm1Tmat
• Allele Name: targeted mutation 1, Tetsuya Matsuguchi
• Allele ID: MGI:3055130
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k8^tm1Tmat/Map3k8^tm1Tmat	involves: 129S/SvEv * C57BL/6	MGI:3055189

Genotype
MGI:3055189

hm1

• Allelic Composition: Map3k8^tm1Tmat/Map3k8^tm1Tmat
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:92844 )

• proliferation of OVA stimulated draining lymph node derived T cells is enhanced in vitro

decreased IgE level ( J:92844 )

• OVA-stimulated production of IgE is decreased in mutants compared to wild-type mice

decreased IgG1 level ( J:92844 )

• IgG1 production is decreased

increased IgG2a level ( J:92844 )

• OVA-stimulated production of IgG2a is increased in mutants compared to wild-type mice

abnormal dendritic cell antigen presentation ( J:92844 )

• MHC class II surface expression on untreated mutant cells is increased compared to wild-type

abnormal cytokine secretion ( J:92844 )

• macrophage LPS-induced production of TNF-alpha is impaired however CpG-induced production of IL-12 and IL-10 is increased

• OVA-sensitized CD4⁺ T cell production of IFN-gamma is increased and production of IL-4 is decreased

hematopoietic system

increased T cell proliferation ( J:92844 )

• proliferation of OVA stimulated draining lymph node derived T cells is enhanced in vitro

decreased IgE level ( J:92844 )

• OVA-stimulated production of IgE is decreased in mutants compared to wild-type mice

decreased IgG1 level ( J:92844 )

• IgG1 production is decreased

increased IgG2a level ( J:92844 )

• OVA-stimulated production of IgG2a is increased in mutants compared to wild-type mice

cellular

increased T cell proliferation ( J:92844 )

• proliferation of OVA stimulated draining lymph node derived T cells is enhanced in vitro