Phenotypes associated with this allele

• Allele Symbol: Bhlhe23^tm1Dbra
• Allele Name: targeted mutation 1, Debra E Bramblett
• Allele ID: MGI:3054837
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bhlhe23^tm1Dbra/Bhlhe23^tm1Dbra	involves: 129S7/SvEvBrd * C57BL/6	MGI:3054927
ht2	Bhlhe23^tm1Dbra/Bhlhe23^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3054929

Genotype
MGI:3054927

hm1

• Allelic Composition: Bhlhe23^tm1Dbra/Bhlhe23^tm1Dbra
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina apoptosis ( J:92623 )

• about a 45% and 32% increase in apoptosis is seen at P8 and P10, respectively, in the inner nuclear layer of the retina

abnormal retina rod bipolar cell morphology ( J:92623 )

• rod bipolar cells are born but fail to properly mature and die between EP8 and P10

abnormal eye electrophysiology ( J:92623 )

• scotopic electroretinogram b-wave results indicate a profound defect in the rod driven circuitry of mutants however a-wave results indicate normal function of the rod photoreceptors

• photopic electroretinogram results indicate a mild defect in the cone driven circuitr

nervous system

abnormal retina rod bipolar cell morphology ( J:92623 )

• rod bipolar cells are born but fail to properly mature and die between EP8 and P10

cellular

increased retina apoptosis ( J:92623 )

• about a 45% and 32% increase in apoptosis is seen at P8 and P10, respectively, in the inner nuclear layer of the retina

Genotype
MGI:3054929

ht2

• Allelic Composition: Bhlhe23^tm1Dbra/Bhlhe23⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

vision/eye

abnormal eye electrophysiology ( J:92623 )

• scotopic electroretinogram b-wave results indicate a mild defect in the rod driven circuitry of mutants and a-wave results indicate normal function of the rod photoreceptors

• photopic electroretinogram results indicate normal function of the cone driven circuitry