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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptpn13tm1Wjh
targeted mutation 1, Wiljan Hendriks
MGI:3054733
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptpn13tm1Wjh/Ptpn13tm1Wjh B6.129P2-Ptpn13tm1Wjh MGI:3852524
hm2
 		Ptpn13tm1Wjh/Ptpn13tm1Wjh involves: 129P2/OlaHsd * C57BL/6 MGI:3054741
cx3
 		Ptpn13tm1Wjh/Ptpn13tm1Wjh
Ptpn3tm1Pdk/Ptpn3tm1Pdk
Ptpn4Gt(OST146128)Lex/Ptpn4Gt(OST146128)Lex 		involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6 MGI:3831001


Genotype
MGI:3852524
hm1
Allelic
Composition		 Ptpn13tm1Wjh/Ptpn13tm1Wjh
Genetic
Background		 B6.129P2-Ptpn13tm1Wjh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn13tm1Wjh mutation (0 available); any Ptpn13 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal glial cell morphology ( J:101070 )
• there are less mean GFAP+ glia in three-day cultures using cells from mice with lens injuries compared to controls
abnormal retina ganglion cell morphology ( J:101070 )
• a smaller percentage of retinal ganglion cells cultured from injuried eyes have neurites compared to controls

vision/eye
abnormal retina ganglion cell morphology ( J:101070 )
• a smaller percentage of retinal ganglion cells cultured from injuried eyes have neurites compared to controls




Genotype
MGI:3054741
hm2
Allelic
Composition		 Ptpn13tm1Wjh/Ptpn13tm1Wjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn13tm1Wjh mutation (0 available); any Ptpn13 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
obese ( J:92590 )
• phenotype disappeared by the F9 generation
• males in early generations developed a mild obese phenotype
• weight difference was first noticeable at 4 months of age
• males were significantly heavier at 15 months of age
• phenotype was mostly due to white adipose tissue

nervous system
abnormal innervation ( J:92590 )
• motor nerve recovery from a sciatic nerve crush lesion was slowed, taking up to 5 weeks as opposed to 3 weeks in controls
• sensory nerve recovery was normal however
abnormal axon morphology ( J:92590 )
• diminished axonal branching observed during the course of recovery from sciatic nerve crush lesion

hematopoietic system
increased T-helper 2 cell number ( J:144351 )
• mice exhibit increased differentiation into T-helper 2 cells compared to in wild-type mice
• however, differentiation into other T-helper cells is normal

immune system
increased T-helper 2 cell number ( J:144351 )
• mice exhibit increased differentiation into T-helper 2 cells compared to in wild-type mice
• however, differentiation into other T-helper cells is normal




Genotype
MGI:3831001
cx3
Allelic
Composition		 Ptpn13tm1Wjh/Ptpn13tm1Wjh
Ptpn3tm1Pdk/Ptpn3tm1Pdk
Ptpn4Gt(OST146128)Lex/Ptpn4Gt(OST146128)Lex
Genetic
Background		 involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn13tm1Wjh mutation (0 available); any Ptpn13 mutation (96 available)
Ptpn3tm1Pdk mutation (0 available); any Ptpn3 mutation (170 available)
Ptpn4Gt(OST146128)Lex mutation (0 available); any Ptpn4 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:144351 )
N
• mice exhibit normal immune compartment and T-helper cell differentiation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory