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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Catb
acatalasemia
MGI:3053604
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Catb/Catb B6.Cg-Catb/Anl MGI:4365629
hm2
Catb/Catb C3.Cg-Catb/Anl MGI:4365605
hm3
Catb/Catb Not Specified MGI:3615785
ht4
Catb/Cat+ Not Specified MGI:4367478


Genotype
MGI:4365629
hm1
Allelic
Composition
Catb/Catb
Genetic
Background
B6.Cg-Catb/Anl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Catb mutation (1 available); any Cat mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole

homeostasis/metabolism
• homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole




Genotype
MGI:4365605
hm2
Allelic
Composition
Catb/Catb
Genetic
Background
C3.Cg-Catb/Anl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Catb mutation (1 available); any Cat mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument

liver/biliary system
• mature males have increased incidence of hepatomas

endocrine/exocrine glands

mortality/aging
• when maintained on a diet containing 1% 3-amino-1H-1,2,4-triazole, homozygotes congenic on a C3H background carrying MMTV have delayed onset of mammary tumors compared with C3H controls carrying MMTV
• homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole
• fewer homozygotes fed a diet containing 1% 3-amino-1H-1,2,4-triazole developed tumors of the hardarian gland or ovaries subsequent to exposure to radiation

homeostasis/metabolism
• when maintained on a diet containing 1% 3-amino-1H-1,2,4-triazole, homozygotes congenic on a C3H background carrying MMTV have delayed onset of mammary tumors compared with C3H controls carrying MMTV
• homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole
• fewer homozygotes fed a diet containing 1% 3-amino-1H-1,2,4-triazole developed tumors of the hardarian gland or ovaries subsequent to exposure to radiation
• a larger percentage of homozygotes fed a diet containing 1% 3-amino-1H-1,2,4-triazole develop liver tumors and these have earlier onset

tumorigenesis
• a larger percentage of homozygotes fed a diet containing 1% 3-amino-1H-1,2,4-triazole develop liver tumors and these have earlier onset
• mature males have increased incidence of hepatomas




Genotype
MGI:3615785
hm3
Allelic
Composition
Catb/Catb
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Catb mutation (1 available); any Cat mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• average serum cholesterol is approximately 94 mg/kg instead of 111.6 mg/kg in control mice (J:5205)
• serum triglyceride levels are much lower than normal (J:5205)
• blood catalase activity in homozygotes is generally below 10 perborate units per ml of whole blood (J:5015)
• very low catalase activity in blood (1.1.-2.4 PU/ml) as compared to wildtype Cata mice (144-155 PU/ml) (J:105024)
• catalase activity in liver (21-28 PU/gm), kidney (6.0-8.7PU/gm), lung (12-17 PU/gm), and intestine (18-19 PU/gm) is lower than wild-type Cata mice (J:105024)
• catalase activity in stomach (26 PU/gm) and brain (37-40 PU/gm) is higher than wild-type Cata mice (J:105024)
• catalase activity in liver and kidney exhibits increased sensitivity to the inhibitory agents guanidine, urea , and aminotriazole relative to wild-type (J:105024)
• catalase activity in liver and kidney exhibits decreased sensitivity to the inhibitory agent azide relative to wild-type (J:105024)

cellular

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Acatalasemia 614097 J:105024




Genotype
MGI:4367478
ht4
Allelic
Composition
Catb/Cat+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Catb mutation (1 available); any Cat mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• blood catalase activity in heterozygotes is generally between 40 and 100 perborate units per ml of whole blood





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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory