All Phenotypes Ciita<tm2Wrth> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ciita^tm2Wrth
targeted mutation 2, Walter Reith
MGI:3052223

Summary

2 genotypes

Allelic Composition	Ciita^tm2Wrth/Ciita^tm2Wrth
Genetic Background	B6.129P2-Ciita^tm2Wrth

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ciita^tm2Wrth mutation (0 available); any Ciita mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:117111 )

N	• mice do not show decreased levels of soluble MHC-II, suggesting that B cells, dendritic cells and stromal cells do not contribute significantly to circulating levels of soluble I-A^b

Allelic Composition	Ciita^tm2Wrth/Ciita^tm2Wrth
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ciita^tm2Wrth mutation (0 available); any Ciita mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

• reduced numbers of CD4+ T cells

• results in lymphopenia

abnormal immunoglobulin level ( J:92170 )

• no antibody response to T-cell dependent antigens

immune system

• reduced numbers of CD4+ T cells

• results in lymphopenia

abnormal immunoglobulin level ( J:92170 )

• no antibody response to T-cell dependent antigens

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
MHC class II deficiency		DOID:5812	OMIM:209920	J:92170

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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