Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfat5tm1Snh mutation
(0 available);
any
Nfat5 mutation
(62 available)
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mortality/aging
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• Background Sensitivity: with fewer than two generations of backcrossing to C57BL/6, embryos begin to die around E14.5
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• after more than 3 generations of backcrossing to C57BL/6, homozygous embryos are present at the expected frequency through E20.5 but die in the immediate perinatal period
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Allelic
Composition |
Nfat5tm1Snh/Nfat5+
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfat5tm1Snh mutation
(0 available);
any
Nfat5 mutation
(62 available)
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hematopoietic system
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• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions
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• thymus cellularity is reduced by 40% compared to wild-type littermates
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• spleen cellularity is reduced by 32% compared to wild-type littermates
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• antigen specific antibody production is reduced 44% compared to wild-type mice
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• total serum IgG but not IgM levels are reduced by 35%
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immune system
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• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions
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• thymus cellularity is reduced by 40% compared to wild-type littermates
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• spleen cellularity is reduced by 32% compared to wild-type littermates
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• antigen specific antibody production is reduced 44% compared to wild-type mice
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• total serum IgG but not IgM levels are reduced by 35%
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endocrine/exocrine glands
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• thymus cellularity is reduced by 40% compared to wild-type littermates
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cellular
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• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions
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Analysis Tools