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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mpz-cre)4Brn
transgene insertion 4, Anton Berns
MGI:3047266
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nf2tm2Gth/Nf2tm2Gth
Tg(Mpz-cre)4Brn/0 		involves: 129P2/OlaHsd * FVB/N MGI:3850391
cn2
 		Nf2tm1Gth/Nf2tm2Gth
Tg(Mpz-cre)4Brn/0 		involves: 129P2/OlaHsd * FVB/N MGI:3850402


Genotype
MGI:3850391
cn1
Allelic
Composition		 Nf2tm2Gth/Nf2tm2Gth
Tg(Mpz-cre)4Brn/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)4Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:63264 )
• all mice die by 19 months of age

neoplasm
increased Schwannoma incidence ( J:63264 )
• 66% of mice develop schwannomas

nervous system
increased Schwannoma incidence ( J:63264 )
• 66% of mice develop schwannomas




Genotype
MGI:3850402
cn2
Allelic
Composition		 Nf2tm1Gth/Nf2tm2Gth
Tg(Mpz-cre)4Brn/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm1Gth mutation (1 available); any Nf2 mutation (65 available)
Nf2tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)4Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory