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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Card11tm1Pngr
targeted mutation 1, Josef M Penninger
MGI:3045950
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Card11tm1Pngr/Card11tm1Pngr involves: 129P2/OlaHsd MGI:3046090
hm2
Card11tm1Pngr/Card11tm1Pngr involves: 129P2/OlaHsd * C57BL/6 MGI:3716872


Genotype
MGI:3046090
hm1
Allelic
Composition
Card11tm1Pngr/Card11tm1Pngr
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11tm1Pngr mutation (0 available); any Card11 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• B cell numbers and differentiation normal in bone marrow
• defect in terminal differentiation of mature B cells
• enhanced cell death in B cells but not T cells
• peritoneal CD5+ B1 cells are absent
• reduced numbers of natural killer cells in spleen
• response to T-cell independent antigens abolished
• B cell proliferation in the spleen markedly impaired
• undetectable
• reduced levels of IgG1, IgG2a, IgGb, IgG3
• impaired response to T-cell dependent antigen
• antigen mediated T-cell activation decreased dramatically

immune system
• B cell numbers and differentiation normal in bone marrow
• defect in terminal differentiation of mature B cells
• enhanced cell death in B cells but not T cells
• peritoneal CD5+ B1 cells are absent
• reduced numbers of natural killer cells in spleen
• response to T-cell independent antigens abolished
• B cell proliferation in the spleen markedly impaired
• undetectable
• reduced levels of IgG1, IgG2a, IgGb, IgG3
• impaired response to T-cell dependent antigen
• antigen mediated T-cell activation decreased dramatically
• defective Il-2 production




Genotype
MGI:3716872
hm2
Allelic
Composition
Card11tm1Pngr/Card11tm1Pngr
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11tm1Pngr mutation (0 available); any Card11 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• stimulation through FcR results in normal production of TNF and Il-2
• stimulation by Toll-like receptor ligands results in normal cytokine production





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last database update
02/13/2018
MGI 6.11
The Jackson Laboratory