Phenotypes associated with this allele

• Allele Symbol: Card11^tm1Pngr
• Allele Name: targeted mutation 1, Josef M Penninger
• Allele ID: MGI:3045950
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Card11^tm1Pngr/Card11^tm1Pngr	involves: 129P2/OlaHsd	MGI:3046090
hm2	Card11^tm1Pngr/Card11^tm1Pngr	involves: 129P2/OlaHsd * C57BL/6	MGI:3716872

Genotype
MGI:3046090

hm1

• Allelic Composition: Card11^tm1Pngr/Card11^tm1Pngr
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal lymphocyte morphology ( J:84036 )

abnormal B cell differentiation ( J:84036 )

• B cell numbers and differentiation normal in bone marrow

• defect in terminal differentiation of mature B cells

• enhanced cell death in B cells but not T cells

absent B-1a cells ( J:84036 )

• peritoneal CD5+ B1 cells are absent

decreased NK cell number ( J:84036 )

• reduced numbers of natural killer cells in spleen

abnormal B cell physiology ( J:84036 )

• response to T-cell independent antigens abolished

decreased B cell proliferation ( J:84036 )

• B cell proliferation in the spleen markedly impaired

decreased immunoglobulin level ( J:84036 )

decreased IgA level ( J:84036 )

decreased IgE level ( J:84036 )

• undetectable

decreased IgG level ( J:84036 )

• reduced levels of IgG1, IgG2a, IgGb, IgG3

decreased IgG1 level ( J:84036 )

decreased IgG2a level ( J:84036 )

decreased IgG2b level ( J:84036 )

decreased IgG3 level ( J:84036 )

decreased IgM level ( J:84036 )

abnormal T cell activation ( J:84036 )

• impaired response to T-cell dependent antigen

• antigen mediated T-cell activation decreased dramatically

immune system

abnormal lymphocyte morphology ( J:84036 )

abnormal B cell differentiation ( J:84036 )

• B cell numbers and differentiation normal in bone marrow

• defect in terminal differentiation of mature B cells

• enhanced cell death in B cells but not T cells

absent B-1a cells ( J:84036 )

• peritoneal CD5+ B1 cells are absent

decreased NK cell number ( J:84036 )

• reduced numbers of natural killer cells in spleen

abnormal B cell physiology ( J:84036 )

• response to T-cell independent antigens abolished

decreased B cell proliferation ( J:84036 )

• B cell proliferation in the spleen markedly impaired

decreased immunoglobulin level ( J:84036 )

decreased IgA level ( J:84036 )

decreased IgE level ( J:84036 )

• undetectable

decreased IgG level ( J:84036 )

• reduced levels of IgG1, IgG2a, IgGb, IgG3

decreased IgG1 level ( J:84036 )

decreased IgG2a level ( J:84036 )

decreased IgG2b level ( J:84036 )

decreased IgG3 level ( J:84036 )

decreased IgM level ( J:84036 )

abnormal T cell activation ( J:84036 )

• impaired response to T-cell dependent antigen

• antigen mediated T-cell activation decreased dramatically

abnormal interleukin-2 secretion ( J:84036 )

• defective Il-2 production

cellular

decreased B cell proliferation ( J:84036 )

• B cell proliferation in the spleen markedly impaired

Genotype
MGI:3716872

hm2

• Allelic Composition: Card11^tm1Pngr/Card11^tm1Pngr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

immune system phenotype ( J:122394 )

N • stimulation through FcR results in normal production of TNF and Il-2

N • stimulation by Toll-like receptor ligands results in normal cytokine production