Phenotypes associated with this allele

• Allele Symbol: Myb^Plt3
• Allele Name: Plt3
• Allele ID: MGI:3045841
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mpl^tm1Wsa/Mpl^tm1Wsa Myb^Plt3/Myb^Plt3	involves: 129S1/Sv * C57BL/6	MGI:3045895
cx2	Mpl^tm1Wsa/Mpl^tm1Wsa Myb^Plt3/Myb^+	involves: 129S1/Sv * C57BL/6	MGI:3045896

Genotype
MGI:3045895

cx1

• Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa; Myb^Plt3/Myb^Plt3
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:89601 )

• lower than expected numbers of homozygotes born in matings of heterozygotes indicating a degree of perinatal or embryonic lethality

hematopoietic system

abnormal megakaryocyte differentiation ( J:89601 )

• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen

abnormal definitive hematopoiesis ( J:89601 )

• numbers of most progenitor cell lines are elevated

abnormal erythropoiesis ( J:89601 )

• defective production of erythroid lineages

• large numbers of erythroid colony forming units but defective maturation

abnormal B cell differentiation ( J:89601 )

• leukopenic

• significantly reduced numbers of B cells in bone marrow and spleen

abnormal thrombopoiesis ( J:89601 )

anemia ( J:89601 )

thrombocytosis ( J:89601 )

• supraphysiological levels

abnormal spleen morphology ( J:89601 )

increased spleen red pulp amount ( J:89601 )

• expanded red pulp with abnormal architecture

decreased spleen B cell follicle size ( J:89601 )

• abnormally small lymphoid follicles

immune system

abnormal B cell differentiation ( J:89601 )

• leukopenic

• significantly reduced numbers of B cells in bone marrow and spleen

abnormal thrombopoiesis ( J:89601 )

abnormal spleen morphology ( J:89601 )

increased spleen red pulp amount ( J:89601 )

• expanded red pulp with abnormal architecture

decreased spleen B cell follicle size ( J:89601 )

• abnormally small lymphoid follicles

cellular

abnormal megakaryocyte differentiation ( J:89601 )

• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen

Genotype
MGI:3045896

cx2

• Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa; Myb^Plt3/Myb⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

hematopoietic system

abnormal megakaryocyte differentiation ( J:89601 )

• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen

abnormal definitive hematopoiesis ( J:89601 )

• numbers of most progenitor cell lines are unchanged

abnormal thrombopoiesis ( J:89601 )

thrombocytosis ( J:89601 )

• amelioration of thrombocytopenia compared to Mpl^tm1Wsa but not to wild-type

cellular

abnormal megakaryocyte differentiation ( J:89601 )

• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen

immune system

abnormal thrombopoiesis ( J:89601 )